Results 111 to 120 of about 2,269,689 (267)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Trends in compassionate use of medicinal products: Israel 2020-2024. [PDF]

Isr J Health Policy Res
Schwartzberg E, Marom E, Finkel-Pekarsky V, Shani S, Kandli MC, Aboukaoud M.   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Development of Technology for Obtaining Extracts from Powdered Herbs and Their Use in Culinary Products and Dishes. [PDF]

Molecules
Zhumaliyeva G, Chomanov U, Kenenbay G, Boribay A, Zhomartkyzy T.   +4 more
europepmc   +1 more source

Potential use of garlic products in ruminant feeding: A review. [PDF]

Anim Nutr, 2023
Ding H, Ao C, Zhang X.
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Perceptions of Prevention and Cessation Ads among US Youth Who Use Multiple Tobacco Products: A Qualitative Study. [PDF]

Nicotine Tob Res
Clark SA, Patterson SL, Duguid I, Noar SM, Lazard AJ, Thrasher JF, Goldstein AO, Kowitt SD.   +7 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Ensuring the Safe Use of Bee Products: A Review of Allergic Risks and Management. [PDF]

Int J Mol Sci
Matuszewska-Mach E, Borysewicz P, Królak J, Juzwa-Sobieraj M, Matysiak J.   +4 more
europepmc   +1 more source

Treatment on Nature's lap: Use of herbal products in the management of hyperglycemia. [PDF]

World J Diabetes, 2023
Giri S, Sahoo J, Roy A, Kamalanathan S, Naik D.   +4 more
europepmc   +1 more source