Results 141 to 150 of about 5,605,727 (282)

Police Use of Force with the Mentally ill

open access: yes, 2016
Police officers experience many difficult situations in their line of duty, but two situations stand out as particularly unsettling for police officers: when they interact with people who are (a) under the influence of drugs or alcohol, and when (b ...
Moore, Chelsea
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Humanitarian Necessity: the Problem of Political Legitimation of Uses of Force

open access: yesУправленческое консультирование, 2018
This article explores the problem addressing the political rationale of the «humanitarian intervention» performed in case of emergency and necessity. The practice of states exhibits the emergence of a new international norm that allows states to perform «
Stanislav Valentinovich Korostelev
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The Evolution of Views on the Rationale for Uses of Force Prior to the Establishment of Modern Institutions

open access: yesУправленческое консультирование, 2018
This article addresses the issue of justification of uses of force in historical perspective. Formation of the modern doctrine of Just War originated in ancient Greece and Rome.
Stanislav Valentinovich Korostelev
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Childcare cost and Spanish mother’s labour force participation [PDF]

open access: yes
In Spain, female labour force participation is among the lowest in Europe. This paper analyzes the extent to which female labour force participation is affected by the cost of formal childcare.
Cristina Borra
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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