Results 191 to 200 of about 5,148,522 (246)

Distinct dopaminergic spike-timing-dependent plasticity rules are suited to different functional roles. [PDF]

Biol Cybern
Sosis B, Rubin JE.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Modeling immersion pathways in XR-based cultural heritage IP narrative experiences: an integrated approach based on TAM, experience economy, and grounded theory. [PDF]

Front Psychol
Liu D, Jung J.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Healthcare consumers' acceptance and use of digital health technology in LMICs and the role of self-efficacy and facilitating conditions: a systematic review and meta-analysis. [PDF]

Lancet Reg Health West Pac
Wang M, Zhao X, Huang K, Li X, Downey L, Hassounah S, Liu X, Jin Y, Ren M.   +8 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Knowledge, Attitude, and Practice on the Use of Contraception Among Female Outpatients in Lagos University Teaching Hospital. [PDF]

Cureus
Naiyeju OJ, Okunade KS, Soibi-Harry AP.
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Intellectual property (IP) rights governance and related value mechanisms in Common European Data Spaces. [PDF]

Data Brief
Rak R.
europepmc   +1 more source

Positive Psychological Well-Being and Determinants of Social Robot Acceptability Among Patients With Heart Failure: Cross-Sectional Questionnaire Study. [PDF]

JMIR Cardio
Maukel LM, Bouchard K, Fiedorowicz JG, Dautenhahn K, Ghafurian M, Coutinho T, McGuinty C, Liu PP, Tulloch H.   +8 more
europepmc   +1 more source