Results 241 to 250 of about 5,877,092 (294)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Distinct dopaminergic spike-timing-dependent plasticity rules are suited to different functional roles. [PDF]

Biol Cybern
Sosis B, Rubin JE.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Healthcare consumers' acceptance and use of digital health technology in LMICs and the role of self-efficacy and facilitating conditions: a systematic review and meta-analysis. [PDF]

Lancet Reg Health West Pac
Wang M, Zhao X, Huang K, Li X, Downey L, Hassounah S, Liu X, Jin Y, Ren M.   +8 more
europepmc   +1 more source

Knowledge, Attitude, and Practice on the Use of Contraception Among Female Outpatients in Lagos University Teaching Hospital. [PDF]

Cureus
Naiyeju OJ, Okunade KS, Soibi-Harry AP.
europepmc   +1 more source

Positive Psychological Well-Being and Determinants of Social Robot Acceptability Among Patients With Heart Failure: Cross-Sectional Questionnaire Study. [PDF]

JMIR Cardio
Maukel LM, Bouchard K, Fiedorowicz JG, Dautenhahn K, Ghafurian M, Coutinho T, McGuinty C, Liu PP, Tulloch H.   +8 more
europepmc   +1 more source

Intellectual property (IP) rights governance and related value mechanisms in Common European Data Spaces. [PDF]

Data Brief
Rak R.
europepmc   +1 more source

Explainable AI for mental health emergency returns: integrating large language models with predictive modeling. [PDF]

JAMIA Open
Ahmed A, Saleem M, Alzeen M, Birur B, Fargason RE, Burk BG, Alhassan A, Al-Garadi MA.   +7 more
europepmc   +1 more source

Association Between Glucagon-Like Peptide-1 Receptor Agonists and Clinical Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Obesity. [PDF]

Drug Des Devel Ther
Huang SC, Wu JY, Kuo CY, Hsu WH, Tsai YW, Lai CC.   +5 more
europepmc   +1 more source