Results 171 to 180 of about 10,961,192 (275)

User-centered design of a patient-generated health data mobile application for primary care visits for older adults with chronic pain. [PDF]

JAMIA Open
Gibson B, Weaver L, Sattar U, Taylor Kelley A, Judd J, Knight SJ, Gordon AJ, Rupper R, Butler JM.   +8 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Using user-centered design to better understand challenges faced during genetic analyses by novice genomic researchers. [PDF]

Front Bioinform
Patel HV, Jarvik GP, Hall TO, Veenstra DL, Xie SJ, Crosslin DR.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Development of a Virtual Transition Program for Adolescents and Young Adults With Type 1 Diabetes: Three-Stage User-Centered Design Study. [PDF]

JMIR Pediatr Parent
Haynes SC, Romano PS, Lopez S, Conboy Heiser E, Reggiardo A, Kwan BM, Morrato EH, Rosenthal JL, Sarkisian M, Leon A, Plante D, Crossen SS.   +11 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Interactive, Personalized Patient Decision Aid for COVID-19 Vaccination in Canada: User-Centered Design Approach. [PDF]

JMIR Hum Factors
Etienne D, Archambault PM, Bogoch II, Chambers CT, Chittle AD, Demers J, Driedger SM, Dubé È, Gagnon MP, Gavaruzzi T, Giguère A, Grandvaux N, Grindrod K, Hakim H, Jeimy S, Kindrachuk J, LeBlanc A, MacDonald SE, Ndjaboue R, Noubi M, Orji R, Paquette JS, Parent E, Renaud JS, Sander B, Taljaard M, Tannenbaum Greenberg D, Tremblay MC, Vohra-Miller S, Welch VA, Witteman HO.   +30 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

iCARE Self-Guided Digital Intervention for Postpartum Depression in Danish Mothers: Formative Research Using User-Centered Design. [PDF]

JMIR Form Res
Marti-Castaner M, Thomsen C, Friis Elliott A, Holt E, Husedzinovic S, Bang Madsen K, Munk-Olsen T.   +6 more
europepmc   +1 more source

User-Centered Design

, 2017
Daniela Doroftei, Geert De Cubber, Rene Wagemans, Anibal Matos, Eduardo Silva, Victor Lobo, Guerreiro Cardoso, Keshav Chintamani, Shashank Govindaraj, Jeremi Gancet, Daniel Serrano   +10 more
openaire   +2 more sources