Results 211 to 220 of about 10,961,192 (275)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Comparing Pregnant and Postpartum Client and Provider Feedback on a Digital Health Intervention for Substance Use Recovery: User-Centered Design Approach. [PDF]

JMIR Form Res
Szlyk H, Paraboschi L, Meigs L, Worley E, Peoples J, Maranets E, Kasson E, Ramsey A, Lau C, Korte K, Cavazos-Rehg P.   +10 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Development of the Healthy Women Intervention to Increase Women's Engagement in Medication Treatment for Opioid Use Disorder: Mixed Methods, User-Centered Design Approach. [PDF]

JMIR Form Res
Sugarman DE, Levine EA, Wang CL, Korte FM, Barbaro NA, Weiss RD, Marsch LA, Campbell AN, Greenfield SF.   +8 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Development of an HPV 16 rapid test founded in user-centered design with primary care clinicians.

Anal Methods
Brennan LP, Hamacher F, Claure LA, Claure Dips AL, Sembian S, Balian LN, Piepho AD, Ermel AC, Linnes JC, Rodriguez NM.   +9 more
europepmc   +1 more source

Development of an mHealth tool to prevent chronic childhood malnutrition in Ecuador: A user-centered design approach in developing contexts. [PDF]

Digit Health
Villena-Esponera MP, Aguilar Gamarra H, Jerves-Córdova C, Molina-Recio G, Caballero M.   +4 more
europepmc   +1 more source

Enhancing LGBTQ+ Inclusivity in an AI-Powered Sexual Health Chatbot: User-Centered Design Approach Through a Nonprofit and Academic Partnership. [PDF]

J Med Internet Res
Liem WW, Casline E, Lorenzo J, Gordon JD, Avila AA, Taylor A, Levitz N, O'Keefe MC, Macapagal K.   +8 more
europepmc   +1 more source

Development of a Tailored Online Video-Based Assistant to Support Prenatal Screening Decisions in Couples With Limited Health Literacy: User-Centered Design Approach. [PDF]

JMIR Form Res
Preuhs K, van Keulen H, Pronk J, Rijnders M, Wils A, Nieuwenhuijze M, Abouri N, van Empelen P.   +7 more
europepmc   +1 more source

Patient-Centered Televisit for Chronic Obstructive Pulmonary Disease Discharge Transitions: User-Centered Design Study. [PDF]

JMIR Hum Factors
Abraham J, Meng A, Caravelli N, Traeger L, Nguyen M, Arora V, Press VG.   +6 more
europepmc   +1 more source