Results 251 to 260 of about 463,209 (335)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

A Smart Glass Telemedicine Application for Prehospital Communication: User-Centered Design Study.

J Med Internet Res
Zhang Z, Bai E, Xu Y, Stepanian A, Kutzin JM, Adelgais K, Ozkaynak M.   +6 more
europepmc   +1 more source

Developing a Mood and Menstrual Tracking App for People With Premenstrual Dysphoric Disorder: User-Centered Design Study. [PDF]

JMIR Form Res
Apsey C, Di Florio A, Stawarz K.
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

An Explanation Interface for Healthy Food Recommendations in a Real-Life Workplace Deployment: User-Centered Design Study.

JMIR Mhealth Uhealth
De Croon R, Segovia-Lizano D, Finglas P, Vanden Abeele V, Verbert K.   +4 more
europepmc   +1 more source

Development and testing of mobile phone text messages for improving maternal and newborn care practice in Jimma Zone, Ethiopia: a user-centered design approach. [PDF]

Pilot Feasibility Stud
Abdissa HG, Duguma GB, Noll J, Sori DA, Koricha ZB.   +4 more
europepmc   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, Volume 15, Issue 7, Page 1144-1158, July 2025.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Development of an online psychological intervention to prevent depression in patients with atrial fibrillation: lessons learned in a user-centered design study. [PDF]

Pilot Feasibility Stud
Helmark C, Ahm R, Brandes A, Skovbakke SJ, Nielsen JC, Frostholm L, Taylor RS, Pedersen SS.   +7 more
europepmc   +1 more source

Design of Customized Mobile Application for Patient Adherence to Oral Anticancer Medications Utilizing User-Centered Design

, 2017
Grace Hsu, Stephanie Y. Crawford, Gennaro Paolella, Sandra Cuéllar, Scott Wirth, Neeta K. Venepalli, Edward Wang, Donna Hughes, Andrew D. Boyd   +8 more
openalex   +2 more sources

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, Volume 15, Issue 7, Page 1054-1067, July 2025.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source