Results 281 to 290 of about 518,430 (330)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Co-Designing the MOSAIC mHealth App With Breast Cancer Survivors: User-Centered Design Approach. [PDF]

JMIR Form Res
Nuseibeh BZ, Johns SA, Shih PC, Lewis GF, Gowan TM, Jordan EJ.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Acceptability and Usability of a Digital Behavioral Health Platform for Youth at Risk of Suicide: User-Centered Design Study With Patients, Practitioners, and Business Gatekeepers. [PDF]

JMIR Form Res
Tse TC, Weiner LS, Funkhouser CJ, DeLuise D, Cullen C, Blumkin Z, O'Brien C, Auerbach RP, Allen NB.   +8 more
europepmc   +1 more source

Developing a Mood and Menstrual Tracking App for People With Premenstrual Dysphoric Disorder: User-Centered Design Study. [PDF]

JMIR Form Res
Apsey C, Di Florio A, Stawarz K.
europepmc   +1 more source

User Requirements and Conceptual Design for an Electronic Data Platform for Interhospital Transfer Between Acute Care Hospitals: User-Centered Design Study.

JMIR Hum Factors
Garabedian P, Kain J, Emani S, Singleton S, Rozenblum R, Samal L, Mueller S.   +6 more
europepmc   +1 more source

Augmented Reality Exergames for Upcoming Cognitive-Motor Rehabilitation: User-Centered Design Approach and User Experience of Healthy Children. [PDF]

JMIR Rehabil Assist Technol
Balloufaud M, Boujut A, Marie R, Guinaldo A, Fourcade L, Hamonet-Torny J, Perrochon A.   +6 more
europepmc   +1 more source

Design of a mobile mental health stigma reduction application for Black adults with depression and anxiety: User centered design (Preprint)

Aderonke Bamgbose Pederson, Ashley A. Knapp, Graham Thornicroft, Margarita Alegrı́a, Madhu Reddy, Blessing Adeleke, Jasmin R. Brooks, Alexander C. Tsai, David C. Mohr   +8 more
openalex   +1 more source

An Explanation Interface for Healthy Food Recommendations in a Real-Life Workplace Deployment: User-Centered Design Study.

JMIR Mhealth Uhealth
De Croon R, Segovia-Lizano D, Finglas P, Vanden Abeele V, Verbert K.   +4 more
europepmc   +1 more source