Results 111 to 120 of about 460,977 (283)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Strengthening Javanese literature material through the Novaja.id application as a form of Javanese cultural preservation

Diglosia
The preservation of regional languages, including Javanese, increasingly requires digital innovations that can support literacy development and sustain readers’ engagement.
Nur Fateah, Subhan Subhan, Yahya Nur Ifriza, Widhiya Ninsiana   +3 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The users centered design of a new digital fluorometer [PDF]

The fluorometer is the equipment used in chemical analysis laboratories, research institutes and nuclear fuel cycle companies. This equipment measures an unknown amount of uranium in ores, rivers, etc.
Colthurst, Carlos Mc Donald, Farias, Marcos Santana, Grecco, Claudio Henrique dos Santos, Pedrosa, Paulo Sergio, Santos, Isaac José Antonio Luquetti dos, Szabó, Andre Pedro   +5 more
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Development of Geographic Information System for Government With Extreme Programming and User-Centered Design Methods

Jurnal Bina Praja
Software development is among the most powerful needs in every organization and industry in the current generation. It is used to help the functionality of their system by using the software development guide named Software Development Life Cycle (SDLC).
Subhan, I Gusti Ayu Suciningsih
doaj  

User-Centered Design of a Computer Vision System for Monitoring PPE Compliance in Manufacturing

Computers
In manufacturing environments, the proper use of Personal Protective Equipment (PPE) is essential to prevent workplace accidents. Despite this need, existing PPE monitoring methods remain largely manual and suffer from limited coverage, significant ...
Luis Alberto Trujillo-Lopez, Rodrigo Alejandro Raymundo-Guevara, Juan Carlos Morales-Arevalo   +2 more
doaj   +1 more source

PEMBANGUNAN APLIKASI INFORMASI TEMPAT KOS BERBASIS WEBSITE MENGGUNAKAN PENDEKATAN USER CENTERED DESIGN [PDF]

, 2018
kebutuhan informasi mengenai tempat kos dibutuhkan. Informasi tempat kos yang lengkap dan mudah diakses melalui website akan memudahkan pencari kos dalam mencari tempat kos.
Ayi Purbasari, DS, Jordiawan Billy Maramis, 153040162   +1 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source