Results 181 to 190 of about 61,015 (266)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Unveiling microbial communities with EasyAmplicon: A user-centric guide to perform amplicon sequencing data analysis. [PDF]

IMetaOmics
Yousuf S, Luo H, Zeng M, Chen L, Ma T, Li X, Zheng M, Zhou X, Chen L, Xi J, Lu H, Cao H, Ma X, Bian B, Zhang P, Wu J, Gan R, Jia B, Sun L, Ju Z, Gao Y, Malik WA, Ma C, Lyu H, Li Y, Hou H, Zhou Y, Bai D, Wang Y, Yang H, Xun J, Du S, Zhang T, Wan X, Peng K, Xu S, Wen T, Chen T, Liu YX.   +38 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

User-Centric Cell-Free Massive MIMO with Low-Resolution ADCs for Massive Access. [PDF]

Sensors (Basel)
Kim JW, Kim HD, Shin KH, Park SW, Seo SH, Choi YJ, You YH, Song HK.   +7 more
europepmc   +1 more source

Overcoming barriers for the adoption of Local Energy and Flexibility Markets: A user-centric and hybrid model.

J Clean Prod, 2021
Pressmair G, Kapassa E, Casado-Mansilla D, Borges CE, Themistocleous M.   +4 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

New colleague or gimmick hurdle? A user-centric scoping review of the barriers and facilitators of robots in hospitals. [PDF]

PLOS Digit Health
Rasmussen MK, Schneider-Kamp A, Hyrup T, Godono A.   +3 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Patient and public involvement in the co-design and assessment of unobtrusive sensing technologies for care at home: a user-centric design approach. [PDF]

BMC Geriatr
Sharma J, Gillani N, Saied I, Alzaabi A, Arslan T.   +4 more
europepmc   +1 more source

The SleepFit Tablet Application for Home-Based Clinical Data Collection in Parkinson Disease: User-Centric Development and Usability Study.

JMIR Mhealth Uhealth, 2021
Mascheroni A, Choe EK, Luo Y, Marazza M, Ferlito C, Caverzasio S, Mezzanotte F, Kaelin-Lang A, Faraci F, Puiatti A, Ratti PL.   +10 more
europepmc   +1 more source