Results 231 to 240 of about 1,828,278 (288)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
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Proceedings of the 7th symposium on Identity and trust on the Internet, 2008
The goal of supporting Single Sign-On to the Web has proven elusive. A number of solutions have been proposed -- and some have even been deployed -- but the capability remains unavailable to most users and the solutions deployed raise concerns for both convenience and security.
Radia J. Perlman, Charlie Kaufman
openaire +2 more sources
The goal of supporting Single Sign-On to the Web has proven elusive. A number of solutions have been proposed -- and some have even been deployed -- but the capability remains unavailable to most users and the solutions deployed raise concerns for both convenience and security.
Radia J. Perlman, Charlie Kaufman
openaire +2 more sources
Proceedings of the second ACM workshop on Digital identity management, 2006
User centricity is a significant concept in federated identity management (FIM), as it provides for stronger user control and privacy. However, several notions of user-centricity in the FIM community render its semantics unclear and hamper future research in this area.
Abhilasha Bhargav-Spantzel +3 more
openaire +2 more sources
User centricity is a significant concept in federated identity management (FIM), as it provides for stronger user control and privacy. However, several notions of user-centricity in the FIM community render its semantics unclear and hamper future research in this area.
Abhilasha Bhargav-Spantzel +3 more
openaire +2 more sources