Results 91 to 100 of about 271,374 (263)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Optimized IRS-Aided UAV Communication for 6G Networks With Phase and User Association Control

IEEE Access
Industry 5.0 relies on advanced automation, high speed connectivity, improved real-time communication support and efficient collaboration to foster an industry ecosystem that is sustainable, innovative and competitive.
Ashu Taneja, Nayef Alqahtani, Ali Alqahtani   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

User Association in the Presence of Jamming in Wireless Networks Using the Whittle Index

IEEE Open Journal of Vehicular Technology
In wireless networks, algorithms for user association, i.e., the task of choosing the base station (BS) that every arriving user should join, significantly impact the network performance. A wireless network with multiple BSs, operating on non-overlapping
Pramod N. Chine, Suven Jagtiani, Mandar R. Nalavade, Gaurav S. Kasbekar   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Uplink Data Rate Maximization in Multi-Cell BackCom NOMA Systems

IEEE Open Journal of the Communications Society
This paper investigates a backscatter communication (BackCom) non-orthogonal multiple access (NOMA) system with numerous base stations (BSs) and backscatter devices (BDs).
Dingjia Lin, Kaidi Wang, Tianqi Wang, Zhiguo Ding   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dynamic Trajectory Control and User Association for Unmanned-Aerial-Vehicle-Assisted Mobile Edge Computing: A Deep Reinforcement Learning Approach

Drones
Mobile edge computing (MEC) has become an effective framework for latency-sensitive and computation-intensive applications by deploying computing resources at network edge.
Libo Wang, Xiangyin Zhang, Kaiyu Qin, Zhuwei Wang, Hang Yin, Jiayi Zhou, Deyu Song   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Toward Proactive, Secure and Efficient Space-Air-Ground Communications: Generative AI-Based DRL Framework

IEEE Open Journal of the Communications Society
The rapid growth of low-Earth-orbit (LEO) satellites has enabled integrated space-air-ground networks to provide seamless connectivity to mobile users.
Amayika Kakati, Guoquan Li, Elhadj Moustapha Diallo, Lilian Chiru Kawala, Nasir Hussain, Abuzar B. M. Adam   +5 more
doaj   +1 more source