Results 181 to 190 of about 520,800 (300)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Kenyan Neonatal Mortality Risk Predictor: Protocol for a User-Centered Design Evaluation.

JMIR Res Protoc
Nyatuka RD, Macharia P, Esther K, Siva F, Muriithi B, Rahman Jabin MS.   +5 more
europepmc   +1 more source

User-centered design approach to visualize PROMs for molecular tumor boards. [PDF]

NPJ Precis Oncol
Bäcker S, Sedlmayr B, Goldammer M, Schuler K, Zerlik M, Strantz C, Unberath P, Gräßel L, Sedlmayr M, Wolfien M.   +9 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Patient Perceptions of Blockchain-Based Health Information Exchange: User-Centered Design Study.

J Med Internet Res
Guse R, Hu S, Thiebes S, Erler C, Caridia C, Stork W, Gersch M, Sunyaev A.   +7 more
europepmc   +1 more source

Development of a Tailored Online Video-Based Assistant to Support Prenatal Screening Decisions in Couples With Limited Health Literacy: User-Centered Design Approach. [PDF]

JMIR Form Res
Preuhs K, van Keulen H, Pronk J, Rijnders M, Wils A, Nieuwenhuijze M, Abouri N, van Empelen P.   +7 more
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Interactive, Personalized Patient Decision Aid for COVID-19 Vaccination in Canada: User-Centered Design Approach.

JMIR Hum Factors
Etienne D, Archambault PM, Bogoch II, Chambers CT, Chittle AD, Demers J, Driedger SM, Dubé È, Gagnon MP, Gavaruzzi T, Giguère A, Grandvaux N, Grindrod K, Hakim H, Jeimy S, Kindrachuk J, LeBlanc A, MacDonald SE, Ndjaboue R, Noubi M, Orji R, Paquette JS, Parent E, Renaud JS, Sander B, Taljaard M, Tannenbaum Greenberg D, Tremblay MC, Vohra-Miller S, Welch VA, Witteman HO.   +30 more
europepmc   +1 more source

Understanding dietitians' technology design needs through user-centered design of a clinical decision support system for patient-centered diabetes education materials. [PDF]

Digit Health
Larson D, Almahmoud E, Rosenthal M, Hudson E, Kelley E, Burgermaster M.   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source