Results 171 to 180 of about 275,923 (298)

Digital room-layout planning for complex manual handling hospital discharges

International Journal of Integrated Care, 2014
Brian Bernard Abraham, Angela Birleson, Stuart Marsden   +2 more
doaj   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Re-Crafting Energy-Related Household Routines. The Integration of Design Methods in Behavioural Change Theory to Foster More Sustainable Routines [PDF]

Pad
The shift towards the adoption of sustainable practices in energy consumption has been boosted by the unprecedented diffusion of digital technologies, such as smart meters and other monitoring devices, that support households in changing their daily ...
Giovanni Profeta, Francesca Cellina, Desirée Veschetti, Evelyn Lobsiger-Kägi, Devon Wemyss, Pasquale Granato   +5 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

What matters to me - a web-based preference elicitation tool for clients in long-term care: a user-centred design. [PDF]

BMC Med Inform Decis Mak, 2020
van Leersum CM, Moser A, van Steenkiste B, Reinartz M, Stoffers E, Wolf JRLM, van der Weijden T.   +6 more
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

User-centred design and evaluation of an mHealth app for fathers' perinatal mental health: a feasibility, acceptability, and usability study. [PDF]

Behav Inf Technol
Teague SJ, Shatte ABR, Fuller-Tyszkiewicz M, Hutchinson DM.   +3 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

User-Centred Design and Development of a Smartphone Application (<i>OverSight</i>) for Digital Phenotyping in Ophthalmology. [PDF]

Healthcare (Basel)
Devraj K, Jones L, Higgins B, Thomas PBM, Moosajee M.   +4 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source