Results 31 to 40 of about 37,804 (303)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Appropriateness of User Fees for Reproductive Health in Malawi [PDF]

open access: yes, 2004
The introduction of cost-sharing strategies, such as user-fees, for health care in developing countries has received increasing attention due to declining Government expenditure on health and reduced donor funding.
Hennink, Monique, Madise, Nyovani
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

User charges [PDF]

open access: yes, 1998
"November 18, 1998."; Discusses 22a-482-3(e) of the Connecticut agency regulations regarding user ...
Goranson, Susan,
core  

Reducing user fees for primary health care in Kenya: Policy on paper or policy in practice?

open access: yesInternational Journal for Equity in Health, 2009
Background Removing user fees in primary health care services is one of the most critical policy issues being considered in Africa. User fees were introduced in many African countries during the 1980s and their impacts are well documented.
Goodman Catherine   +4 more
doaj   +1 more source

How Did Local Governments Recover Their Financial Condition? Lessons from Citizen Participation

open access: yesTransylvanian Review of Administrative Sciences, 2023
This study offers lessons for overcoming future economic crises by examining whether democratic management helped local governments recover their financial condition.
Ji Hyung Park
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

International aeronautical user charges [PDF]

open access: yes, 1985
February 1985Includes bibliographical referencesIntroduction: 1.1 BACKGROUND AND MOTIVATION Very few issues relating to the international air transportation industry are today as divisive as those pertaining to user charges imposed at international ...
Odoni, Amedeo R.
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

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