Results 71 to 80 of about 781,601 (304)

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Free for All

Journal of New Librarianship
Periodic website redesign projects have become essential -- though often complex and costly -- measures that libraries take to ensure users’ ease of access to resources.
Victoria Elmwood, Elizabeth Kelly, Jessica Perry, William Ransom, Lucy Rosenbloom, Michael Truran   +5 more
doaj   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Analysis of User Experience in the Design of the AMGM Lab Mobile Application Using the User Experience Questionnaire (UEQ) for Enhanced Efficiency

Journal of Applied Informatics and Computing
AMGM mobile Lab application is a design application supporting documentation of water sample management data. There is a management support system in the form of an intranet. Nevertheless, access to the system is restricted to the office. Naturally, this
Indah Rahma Ilmiana, Chanifah Indah Ratnasari   +1 more
doaj   +1 more source

Penerapan Metode UCD (User Centered Design) Pada E-Commerce Putri Intan Shop Berbasis Web

Jurnal Teknologi dan Sistem Informasi, 2017
Pertumbuhan pesat pangsa pasar e-commerce di Indonesia memang sudah tidak bisa diragukan lagi. Dengan jumlah pengguna internet yang mencapai angka 82 juta orang atau sekitar 30% dari total penduduk di Indonesia, pasar e-commerce menjadi tambang emas yang
Intan Sandra Yatana Saputri, Mardhiah Fadhli, Ibnu Surya   +2 more
doaj   +1 more source

Contextually proximate approach to develop smart user interface [PDF]

arXiv, 2015
Researchers and experts are taking efforts in delivering an optimal user experience from a long time. Computer interfaces are being developed to keep user 'in the flow' as well as for making users more connected to the real world wile using virtual environment.
arxiv  

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Mobile AR Interaction Design Patterns for Storytelling in Cultural Heritage: A Systematic Review

Multimodal Technologies and Interaction
The recent advancements in mobile technologies have enabled the widespread adoption of augmented reality (AR) to enrich cultural heritage (CH) digital experiences. Mobile AR leverages visual recognition capabilities and sensor data to superimpose digital
Andreas Nikolarakis, Panayiotis Koutsabasis   +1 more
doaj   +1 more source

Human connections. Design interactive artefacts through narration and speculation

Agathón, 2020
The research in design today is looking for solutions that repair the problems that design itself has created, however, focusing only on reactive attitude is no longer sufficient for the current complexity of the system.
Andrea Di Salvo, Andrea Arcoraci
doaj   +1 more source