Results 121 to 130 of about 1,226,701 (337)
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
eCOMBINE: framework for energy, comfort, behaviour and a multi-domain environment
Buildings & CitiesOffice workers respond to a variety of environmental and contextual stimuli, which can influence their comfort and behaviour. Although recent models address the unpredictability of human–building interactions, they often neglect multi-domain factors and ...
Verena M. Barthelmes +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Adaptive querying for reward learning from human feedback
Frontiers in Robotics and AILearning from human feedback is a popular approach to train robots to adapt to user preferences and improve safety. Existing approaches typically consider a single querying (interaction) format when seeking human feedback and do not leverage multiple ...
Yashwanthi Anand +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Empowering Healthcare Through User Feedback: A Multidimensional Analysis of the Knowledge. [PDF]
Patient Prefer Adherence, 2023 Richards M +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
User feedback assessment of region-focused mobility-as-a-service bundles
Multimodal TransportationMobility-as-a-Service (MaaS) is viewed as a prospective approach to encourage sustainable mobility. To ensure the effectiveness of MaaS subscription plans, continuous feedback and communication with users are crucial.
Sofia Suárez +3 more
doaj +1 more source
User Feedback Practices in Continuous Software Engineering
, 2020 Jan Ole Johanßen +3 more
openalex +1 more source