Results 91 to 100 of about 187,835 (253)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Content Marketing in the Digital Transformation Era: Trends and Best Practices

open access: yesProceedings
In the digital transformation era, content marketing has emerged as a critical strategy for organizations seeking to connect with their audiences in meaningful ways [...]
Ashwani Sharma
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Examining the impact of advertising, firm-generated content, and user-generated content on customers’ propensity to buy food online

open access: yesFuture Business Journal
This study examines the impact of advertising, firm-generated content (FGC), and user-generated content (UGC) on the customer's propensity to buy food online. An online survey questionnaire was developed and administered to users of food aggregators. The
Sudharshini Vasan   +2 more
doaj   +1 more source

Data-driven strategies in operation management: mining user-generated content in Twitter. [PDF]

open access: yesAnn Oper Res, 2022
Saura JR   +2 more
europepmc   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The Influence of User-Generated Content on Tourists’ Choices

open access: yesTržište, 2015
Most research on user-generated content (UGC) has focused on readers of comments and reviews. However, very little research is aimed at profiling travelers based on the extent to which their decisions regarding the choice of hotels are influenced by UGC.
Giacomo Del Chiappa   +2 more
doaj  

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