Results 131 to 140 of about 5,316,996 (342)

Connected innovation: an international comparative study that identifies mixed modes of innovation [PDF]

open access: yes, 2011
This paper offers a new angle on innovation modalities by adopting a recently emerging approach towards identifying innovation typologies via exploratory data analysis techniques with the aim to tease out some underlying latent variables that represent ...
Frenz, Marion, Lambert, R.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Evidence from the Patent Record on the Development of Cash Dispensing Technology [PDF]

open access: yes
There are but a handful of systematic studies on the history of automated teller machines (ATMs) yet all fail to address the issue of paternity while perpetrating ‘common wisdom’ beliefs.
Batiz-Lazo, Bernardo, Reid, Robert J. K.
core   +1 more source

Community as a locus of innovation: co-innovation with users in the creative industries [PDF]

open access: yes, 2011
The aim of the paper is to characterize innovation with user communities and to explore managerial implications for creative industries. Based on four case studies, we explore the interrelations between the firm and user communities.
Mangematin, Vincent, Parmentier, Guy
core   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Linking scientific and practical knowledge in innovation systems [PDF]

open access: yes
New research indicates that firms combining the science-based STI (Science, Technology, Innovation) and the experience-based DUI (Doing, Using, Interacting) modes of innovation are more efficient when it comes to improving innovation capacity and ...
Isaksen, Arne, Nilsson, Magnus
core  

Facilitating User Driven Innovation – A Study of Methods and Tools at Herlev Hospital [PDF]

open access: yes, 2011
Purpose: To present the preliminary research results of user driven innovation methods at healthcare facilities and their relevance to research and practice. Background/Approach: The paper is based on a case study conducted at the Gynaecologic Department
Fronczek-Munter, Aneta
core   +1 more source

Living Innovation Laboratory Model Design and Implementation

open access: yes, 2015
Living Innovation Laboratory (LIL) is an open and recyclable way for multidisciplinary researchers to remote control resources and co-develop user centered projects.
Zheng, Yuting
core   +1 more source

User Innovation in Healthcare

open access: yesSpringerBriefs in Health Care Management and Economics, 2020
Francesco Schiavone
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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