Results 71 to 80 of about 501,868 (357)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Knowledge Transfer-Enhanced Contrastive Learning for Long-Tailed User Recommendation
IEEE AccessIn recommendation systems, Graph Convolutional Networks (GCNs) have shown superior performance by exploiting high-order relationships. However, generating accurate recommendations for long-tailed users with sparse interactions in large-scale scenarios ...
Xiangling Lei, Hongwei Zhang
doaj +1 more source
From ‘other’ to involved: User involvement in research: An emerging paradigm [PDF]
, 2013 This article has been made available through the Brunel Open Access Publishing Fund. Copyright @ 2013 The Author(s). This is an Open Access article.
Beresford, P
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
USER INVOLVEMENT IN SOCIAL WORK EDUCATION: MACEDONIAN PERSPECTIVE
Ljetopis socijalnog rada, 2009 Involving service users and carers in the education and training of social workers is higher on the policy and practice agenda in the developed countries than ever before.
Suzana Bornarova
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
USER MOTIVATION AND KNOWLEDGE SHARING IN IDEA CROWDSOURCING [PDF]
International Journal of Innovation Management, 2014 We investigate how the propensity to trust, intrinsic motivation, and extrinsic motivation drive the intentions of individuals to share knowledge in idea crowdsourcing. Building on motivation theories and Uses & Gratifications (U&G) approach, we conducted a web-based survey within IdeasProject, an open innovation and brainstorming community ...
MIIA KOSONEN +3 more
openaire +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source