FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Understanding the user - why, what and how? [PDF]
, 1995 Explains the need, importance, purposes and scope of user studies, discusses procedure for conducting sound user studies together with associated problems of research like selection of problem, formulation of hypothesis, design of study, sampling ...
Sridhar, M. S.
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Shared decision making in the social services? Reasons to consider when choosing methods for service user participation. [PDF]
J Eval Clin Pract, 2020 Nykänen P.
europepmc +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Citizens’ participation in policy-making [in Europe]’, CINEFOGO Working Paper [PDF]
, 2008 The paper initially emerged from the papers delivered at the first WP14 workshop at UWE in Bristol in February 2007. The conference brought together a range of academics and practitioners from mainly EU countries.
Grimshaw, Lucy, Lever, John
core
Digital recovery networks: Characterizing user participation, engagement, and outcomes of a novel recovery social network smartphone application. [PDF]
J Subst Abuse Treat, 2020 Ashford RD +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Decentralizing water resource management : economic incentives, accountability, and assurance [PDF]
Private sector involvement and user participation in water resource management are not new, say the authors. They give examples that demonstrate how willing users and the private sector are able to improve water use and play a larger role in water ...
DEC +2 more
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Eliciting recovery narratives in global mental health: Benefits and potential harms in service user participation. [PDF]
Psychiatr Rehabil J, 2020 Kaiser BN +5 more
europepmc +1 more source