Results 61 to 70 of about 306,057 (287)

Interference Management with Partial Uplink/Downlink Spectrum Overlap

, 2015
Simultaneous reuse of spectral resources by uplink and downlink, denoted as in-band full duplex (FD) communication, is promoted to double the spectral efficiency when compared to its half-duplex (HD) counterpart. Interference management, however, remains
Alouini, Mohamed-Slim, Dahrouj, Hayssam, Elsawy, Hesham, Randrianantenaina, Itsikiantsoa   +3 more
core   +1 more source

Cyclic Bayesian Attack Graphs: A Systematic Computational Approach

, 2020
Attack graphs are commonly used to analyse the security of medium-sized to large networks. Based on a scan of the network and likelihood information of vulnerabilities, attack graphs can be transformed into Bayesian Attack Graphs (BAGs).
Mace, John, Matthews, Isaac, Soudjani, Sadegh, van Moorsel, Aad   +3 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Probabilistic modeling of vulnerability of road infrastructures to floods

E3S Web of Conferences, 2016
Factors which contribute to the vulnerability of physical elements such as road infrastructures to a natural hazard such as a flood event are pervaded by uncertainty due to the complexity of the hazard, of the vulnerable infrastructure and of their ...
Uzielli Marco, Vangelsten Bjørn Vidar, Eidsvig Unni   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Analysis of the NIST database towards the composition of vulnerabilities in attack scenarios [PDF]

, 2008
The composition of vulnerabilities in attack scenarios has been traditionally performed based on detailed pre- and post-conditions. Although very precise, this approach is dependent on human analysis, is time consuming, and not at all scalable.
Franqueira, Virginia Nunes Leal, van Keulen, Maurice   +1 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Rethinking consumer vulnerability in the legal services sector: The case for the Universal Practice Approach (UPA)

Oñati Socio-Legal Series
Vulnerability remains a contested concept in legal services, with traditional models often reinforcing stigma through risk-based identification. This article introduces the Universal Practice Approach (UPA), which reframes vulnerability as a universal ...
Paolo Baffero, Harriet Pierpoint
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Towards Improved Protection of Vulnerable Road Users [PDF]

Transactions on Transport Sciences, 2011
The paper aims at reducing injury risk and an overall increase in pedestrian passive safety by proposing pedestrian friendly vehicle design. Statistical data are used to identify the most vulnerable population group also regarding the economic losses caused by deaths or medical treatment. An age dependent anthropometric approach enables the development
L. Hynčík, H. Čechová, J. Maňas, J. Kovanda   +3 more
openaire   +1 more source