Results 101 to 110 of about 5,239,056 (367)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Health information needs and feedback of users in the online TCM community.
PLoS ONETo improve the information service quality of the online Traditional Chinese Medicine (TCM) community, this study investigated users' information needs, feedback and the relationship between them.
Lei Nie, Jiayi Xu, Ruojia Wang
doaj +1 more source
Infrastructuring for Crowdsourced Co-Design
Interaction Design and Architecture(s), 2019 User satisfaction determines the quality of a product idea. Yet it is hard to accomplish when designers are isolated from their users, creating a gap in the design practices.
Delcy Carolina Bonilla Oliva +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The power of combined modalities in interactive robot learning
Frontiers in Robotics and AIWith the continuous advancement of Artificial intelligence (AI), robots as embodied intelligent systems are increasingly becoming more present in daily life like households or in elderly care.
Helen Beierling +2 more
doaj +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Designing toy prototypes: an exploration of how fidelity affects children’s feedback on prototypes
Design ScienceTesting prototypes with users is essential when developing new products. This qualitative study examines and organizes users’ (children) feedback on physical toy prototypes at various fidelity levels; the data collected comes from a multidisciplinary ...
Andria Codner, Carlye Anne Lauff
doaj +1 more source
User interface adaptation based on user feedback and machine learning
Proceedings of the companion publication of the 2013 international conference on Intelligent user interfaces companion, 2013 With the growing need for intelligent software, exploring the potential of Machine Learning (ML) algorithms for User Interface (UI) adaptation becomes an ultimate requirement. The work reported in this paper aims at enhancing the UI interaction by using a Rule Management Engine (RME) in order to handle a training phase for personalization.
Mezhoudi, Nesrine +1 more
openaire +2 more sources
Entity Summarization with User Feedback [PDF]
, 2020 Semantic Web applications have benefited from entity summarization techniques which compute a compact summary for an entity by selecting a set of key triples from underlying data. A wide variety of entity summarizers have been developed. However, the quality of summaries they generate are still not satisfying, and we lack mechanisms for improving ...
Liu, Qingxia +5 more
openaire +1 more source