Results 121 to 130 of about 3,388,963 (307)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
An overview of the use of newer antiepileptic drugs in psychiatry
Archives of Mental Health, 2012 Antiepileptic drugs (AEDs) are increasingly being used for psychiatric indications. Few of them have FDA approval, while many others are used off-label.
N Prasanna Kumar, Rajshekhar Bipeta
doaj
TRACKING CHANGES IN USES AND USERS OF A WEB-BASED INFORMATION SYSTEM OVER TIME USING SERVER LOGS
This study analyzes the uses and users of the Strategic Soybean Information System (StratSoy). It identifies: the uses and users of StratSoy web site; patterns of use; and the determinants of use.
Nwoha, Ogbonnaya John
core
The uses of multimedia: three digital literacy case studies
, 2008 Researchers from CCI identify some tensions between formal education and informal learning in the uses of popular literacy since the nineteenth century, in order to argue for a \u27demand-led\u27 model of education in digital literacy.
McWilliam, Kelly +9 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2013 John Munro (1849–1930) fue un escritor británico especializado en difundir la historia de la electricidad y en promover los usos comerciales de la misma.
Munro, John
core
, 2018 This paper examines the extent to which participation in microfinance programs improves health service uses and health-seeking behaviour of participants.
Bhuiya, Mohammad Monzur Morshed +3 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source