Usnic Acid Exerts Antiproliferative and Apoptotic Effects by Suppressing NF-B p50 in DU145 Cells
European Journal of Biology, 2023 Objective: Nuclear factor kappa B (NF-κB) is one pathway that controls the expression of genes involved in many cancer events such as proliferation, apoptosis, metastasis, and invasion.
Ömer Erdoğan +2 more
doaj +1 more source
Usnic acid improves memory impairment after cerebral ischemia/reperfusion injuries by anti-neuroinflammatory, anti-oxidant, and anti-apoptotic properties [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Cerebral ischemia/reperfusion causes complex pathological mechanisms that lead to brain tissue damage. Usnic acid is a lichen secondary metabolite that has many different biological properties including anti-inflammatory and anti-oxidant ...
Soheila Erfani +5 more
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Docking Studies of Usnic Acid and Sodium Usnate on SARS CoV-2 Main Protease and Spike Protein RBD [PDF]
, 2020 SARS CoV-2 a pandemic influenza like infectious disease emerged in December 2019 has spread throughout the world within few months. Scientists are trying their best to find medicine and vaccine.
Roopa, Guthappa
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Effect of (+) usnic Acid on Pigment Production in Bacteria
Journal of Pure and Applied Microbiology, 2022 Antibiotic resistance is a universal problem in bacterial infections. Hence it gives high priority for new therapeutic methods to alternate conventional antibiotic treatment.
V. Rajeswari +3 more
doaj +1 more source
Toxicity of Usnic Acid: A Narrative Review. [PDF]
J Toxicol, 2022 Usnic acid (UA) is a dibenzofuran derivative naturally present in lichens, organisms resulting from the symbiosis between a fungus and a cyanobacterium, or an alga. UA shows antimicrobial, antitumor, antioxidant, analgesic, anti-inflammatory as well as UV-protective activities.
Croce N, Pitaro M, Gallo V, Antonini G.
europepmc +4 more sources
In-silico Studies of Usnic Acid against DENV-3 Methyltransferase [PDF]
, 2023 There is currently no antiviral medication for dengue, a highly fatal tropical infectious disease spread by the Aedes aegypti and Aedes albopictus mosquitoes.
Huq, A.K.M. Moyeenul +3 more
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Lichen secondary metabolites in Flavocetraria cucullata exhibit anti-cancer effects on human cancer cells through the induction of apoptosis and suppression of tumorigenic potentials. [PDF]
PLoS ONE, 2014 Lichens are symbiotic organisms which produce distinct secondary metabolic products. In the present study, we tested the cytotoxic activity of 17 lichen species against several human cancer cells and further investigated the molecular mechanisms ...
Thanh Thi Nguyen +13 more
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Molecules, 2021 Usnic acid is the best-studied lichen metabolite, presenting several biological activities, such as antibacterial, immunostimulating, antiviral, antifungal, anti-inflammatory, and antiparasitic agents; despite these relevant properties, it is a ...
Hallysson Douglas Andrade de Araújo +5 more
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The RP-HPLC method for analysis of usnic acid as potential marker of herbal drugs-based formulations containing Usnea barbata [PDF]
Journal of the Serbian Chemical Society, 2022 The aim of this study was to develop and validate a sensitive RP-HPLC method for the determination of usnic acid, as a potential marker substance of the herbal product for oromucosal use being a complex mixture of plant extracts and an essential oil ...
Tadić Vanja +6 more
doaj +1 more source
Hepatotoxicity of usnic acid and underlying mechanisms. [PDF]
J Environ Sci Health C Toxicol CarcinogSince usnic acid was first isolated in 1844 as a prominent secondary lichen metabolite, it has been used for various purposes worldwide. Usnic acid has been claimed to possess numerous therapeutic properties, including antimicrobial, anti-inflammatory, antiviral, anti-proliferative, and antipyretic activities.
Chen S, Ren Z, Guo L.
europepmc +3 more sources