Results 191 to 200 of about 79,268 (344)

Real‐World Data Analysis of Genomic Alterations Detected by a Dual DNA–RNA Comprehensive Genomic Profiling Test

Cancer Science, EarlyView.
This study analyzed 1356 cases using GenMineTOP, Japan's first dual DNA–RNA CGP test, and identified oncogenic alterations in 91.5% of cases. The RNA panel detected 105 fusion events, including 11 NTRK fusions. Furthermore, the analysis clarified the independent effects of genomic abnormalities and cancer type on RNA expression, providing valuable ...
Kousuke Watanabe, Miho Ogawa, Aya Shinozaki‐Ushiku, Shuichi Tsutsumi, Kenji Tatsuno, Hiroyuki Aburatani, Hidenori Kage, Katsutoshi Oda   +7 more
wiley   +1 more source

Deep Phenotyping of Pathology‐Confirmed Benign Lesions in PTEN Hamartoma Tumor Syndrome Patients

Clinical Genetics, EarlyView.
Gastrointestinal, skin, thyroid, and vascular lesions are frequently present in PTEN Hamartoma Tumor Syndrome patients with little to no difference between sexes or by index status. Early‐onset lipomas (< 20 years) may be useful for early recognition of patients, and uterine polyps should be considered for inclusion as a PHTS‐related lesion.
Ane J. Schei‐Andersen, Janneke H. M. Schuurs‐Hoeijmakers, Rachel van der Post, Arjen R. Mensenkamp, Jolanda Schieving, PTEN Study Group, Muriel A. Adank, Mirjam de Jong, Marjolijn C.J. Jongemans, Liselotte P. van Hest, Yvette van Ierland, Edward M. Leter, Maartje Nielsen, Janet R. Vos, Nicoline Hoogerbrugge   +14 more
wiley   +1 more source

THER: Integrative Web Tool for Tumour Hypoxia Exploration and Research

Cell Proliferation, EarlyView.
THER: Integrative Web Tool for Tumor Hypoxia Exploration and Research.
Yasi Zhang, Huiying Liu, Pengpeng Zhang, BiCheng Ye, Haoxuan Ying, Hong Yang, Jian Zhang, Nan Zhang, Kailai Li, Ting Wei, Aimin Jiang, Anqi Lin, Peng Luo   +12 more
wiley   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

[Women with invasive uterine cervical neoplasm: family support as a help]. [PDF]

, 2007
Dejeane de Oliveira Silva Barros, Regina Lúcia Mendonça Lopes   +1 more
openalex  

Diagnostic value of Cyto-pick compared to cotton swab sampling for uterine cervical neoplasm screening in pregnant women.

, 1999
Yoichi Kobayashi, Kaoru Saito, Yosuke KANISHI, Seiko Noda, Kiyoshi Shoji, Hiroshi Mizuhara, Akira Amemiya, Eio Atari, Mamoru Tadokoro, Sakiko Hoshikawa   +9 more
openalex   +2 more sources

The G protein‐coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells

The FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara, Eda Dogan, Vildan Bozok, Cagdas Aktan, Ece Cakiroglu, Zuhal Eroglu, Duygu Aygunes Jafari, Kemal Sami Korkmaz, Serif Senturk, Buket Kosova   +9 more
wiley   +1 more source

A case report of a patient with bulky uterine cervical neoplasm who achieved complete response with “intentional internal high-dose policy” high-dose-rate interstitial brachytherapy

, 2020
Tairo Kashihara, Kazuma Kobayashi, Kotaro Iijima, Naoya Murakami, Ken Yoshida, Kae Okuma, Satoshi Nakamura, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Yuko Nakayama, Tomoyasu Kato, Takashi Uno, Jun Itami   +13 more
openalex   +1 more source

Effects of ovariectomy‐induced osteoporosis and two photobiomodulation protocols on the repair of apical periodontitis in Wistar rats: A microCT study

International Endodontic Journal, EarlyView.
Abstract Aim Osteoporosis is a disease that is related to a higher prevalence and greater volumes of apical periodontitis. The purpose of this study was to evaluate the effect of ovariectomy‐induced osteoporosis and high‐ or low‐level laser photobiomodulation (PBM) on the repair of apical periodontitis (AP) in adult female Wistar rats.
Carolina Horn Troian‐Michel, Bruna Barcelos Só, Lauren Frenzel Schuch, Grazielle Oliveira Stelter, Tuany Rafaeli Schmidt, Joana Letícia Schorr, Daniela Campagnol, Tuane Nerissa Alves Garcez, Gabriel Barcelos Só, Thalita Ayres Arrué, Theodoro Weissheimer, Manoela Domingues Martins, Marcus Vinicius Reis Só   +12 more
wiley   +1 more source

Prevalence of cervical intraepithelial neoplasia and invasive carcinoma based on cytological screening in the region of Campinas, São Paulo, Brazil

Cadernos de Saúde Pública, 2004
This study aimed to estimate and analyze the prevalence of cervical intraepithelial neoplasia (CIN) and invasive cervical carcinoma based on cytological diagnosis. The study included 120,635 women undergoing cytological exams in public health services in
d'Ottaviano-Morelli Maria Gabriela L., Zeferino Luiz, Cecatti José Guilherme, Terrabuio Débora Raquel, Martinez Edson Zangiacomi   +4 more
doaj