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Uterine Leiomyomas: An ENIGMA

Journal of Mid-Life Health, 2016
Introduction: Leiomyomas are benign tumors composed of smooth muscle cells and varying amounts of fibrous connective tissue commonly encountered in women of reproductive age group.
Kempula Geethamala, Venkataramappa Srinivasa Murthy, Bangalore Ramalingiah Vani, Sudha Rao   +3 more
doaj   +4 more sources

Hyaline and Cystic Degeneration of Uterine Leiomyomas: CT and MR Imaging with Histopathological Sample Analyses [PDF]

Diagnostics, 2023
Leiomyomas are the most common solid benign uterine neoplasms; they are usually asymptomatic and are identified incidentally. Yet, responsive to stimulation by estrogens, leiomyomas may expand, potentially outgrowing their blood supply to undergo ...
Camilo G. Sotomayor, Carla Parra, Maximiliano Miranda, Juan Salvador Casas, Gonzalo Cárdenas, Álvaro Sanhueza, Francisca Araya, Iván Gallegos, Sebastián Yévenes   +8 more
doaj   +2 more sources

MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas [PDF]

JCI Insight, 2023
Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiomyomas that ...
Azna Zuberi, Yongchao Huang, Ariel J. Dotts, Helen Wei, John S. Coon V, Shimeng Liu, Takashi Iizuka, Olivia Wu, Olivia Sotos, Priyanka Saini, Debabrata Chakravarti, Thomas G. Boyer, Yang Dai, Serdar E. Bulun, Ping Yin   +14 more
doaj   +2 more sources

Uterine leiomyoma [PDF]

Orvosi Hetilap, 2010
A leiomyoma, a méh benignus, simaizom-eredetű daganata, a méheltávolítás leggyakoribb javallatát képezi világszerte. A tumor a nők akár 20–25%-ában is kialakulhat, olyan tüneteket okozva, mint vérzészavar, alhasi fájdalom, esetenként infertilitás. A kezelés fő irányát mind a mai napig a sebészi terápia jelenti, ugyanakkor mind több csekély invazivitású
Eva, Csatlós, János, Rigó, István, Szabó, Zsolt, Nagy, József Gábor, Joó   +4 more
  +5 more sources

Effects of bisphenol A on uterine leiomyoma: In vitro and in vivo evaluation with mechanistic insights related to XBP1

Ecotoxicology and Environmental Safety, 2022
The incidence rate of human uterine leiomyomas is over 70% in the women of childbearing age, which has caused serious health and financial burden. Our previous study confirmed that Bisphenol A (BPA)，representative environmental estrogen, promoted the ...
Zemin Li, Han Yin, Kai Chen, Bo Ding, Jingyun Xu, Mulan Ren, Chuan Zhang, Yang Shen   +7 more
doaj   +1 more source

The Management of Uterine Leiomyomas [PDF]

Journal of Obstetrics and Gynaecology Canada, 2015
The aim of this guideline is to provide clinicians with an understanding of the pathophysiology, prevalence, and clinical significance of myomata and the best evidence available on treatment modalities.The areas of clinical practice considered in formulating this guideline were assessment, medical treatments, conservative treatments of myolysis ...
Vilos, George A., Allaire, Catherine, Laberge, Philippe Yves, Leyland, Nicholas, Vilos, Angelos G., Murji, Ally, Chen, Innie   +6 more
openaire   +5 more sources

Uterine leiomyoma with tubules [PDF]

International Seminars in Surgical Oncology, 2008
We report two cases of "uterine leiomyoma with tubules" as a new pathological entity. Since these are biphasic neoplasms (composed by epithelial and mesenchimal elements), the differential diagnosis is between mixed mullerian tumors and uterine tumors resembling ovarian sex cord tumors (UTROSCTs).
Pusiol, Teresa, Parolari, Anna, Piscioli, Francesco   +2 more
openaire   +2 more sources

Uterine torsion in non-gravid women: A case report and review of cases reported in the last 20 years

SAGE Open Medical Case Reports, 2021
Uterine torsion is defined as a rotation of >45° around the long axis of the uterus. Uterine torsion is an uncommon event but is even rarer in non-gravid women, with only 25 cases reported in the last 20 years.
Harunobu Matsumoto, Yoko Aoyagi, Taisuke Morita, Kaei Nasu   +3 more
doaj   +1 more source

Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas. [PDF]

PLoS ONE, 2012
Uterine leiomyomas (uterine fibroids) arise from smooth muscle tissue in the majority of women by age 45. It is common for these clonal tumors to develop from multiple locations within the uterus, leading to a variety of symptoms such as pelvic pain ...
Megan M McGuire, Alexander Yatsenko, Lori Hoffner, Mirka Jones, Urvashi Surti, Aleksandar Rajkovic   +5 more
doaj   +1 more source

Two Rare Cases of Uterine Leiomyosarcomas Originating from Submucosal Leiomyomas Proved by Their Immunohistochemistry Profiles [PDF]

International Journal of Fertility and Sterility, 2020
The most common mesenchymal tumours of the uterine corpus originate from smooth muscle cells. Leiomyomas arecommonly found in women of child bearing age; however, leiomyosarcomas occur later in life (50-55 years of age).Most uterine leiomyosarcomas occur
Hossein Ghorbani, Mohammad Ranaee, Zeinab Vosough   +2 more
doaj   +1 more source