Results 91 to 100 of about 702,089 (378)

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Hemangioma of the uterus [PDF]

Archive of Oncology, 2005
This paper presents a case of a patient with hemangioma of the uterus, which is one of the very rare localizations for this type of tumors. Hemangiomas are tumors that originate from blood vessels and are more often found on the skin or in the liver.
Mastilović Katarina, Rajović Jelka, Žikić Dragan, Stojiljković Bratislav   +3 more
doaj   +1 more source

Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer [PDF]

, 2019
Aims Lymphovascular space invasion (LVSI) in endometrial cancer (EC) is an important prognostic variable impacting on a patient's individual recurrence risk and adjuvant treatment recommendations.
Bartosch, Carla, Bosse, Tjalling, Genestie, Catherine, Lax, Sigurd F, McCluggage, W Glenn, Nout, Remi, Oosting, Jan, Peters, Elke E M, Singh, Naveena, Smit, Huub C S H, Smit, Vincent T H B M, Van de Vijver, Koen   +11 more
core   +2 more sources

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Survival analysis of patients with rare tumors of the uterine corpus – carcinosarcoma [PDF]

Vojnosanitetski Pregled
Background/Aim. Uterine carcinosarcoma (UCS), formerly known as malignant mixed Müllerian tumor, is a rare, aggressive malignancy of the female genital tract.
Stevanović Nemanja, Mandić Aljoša, Maričić Slobodan, Nadj Gabriel Stefan, Maksimović Tamara, Stanulović Nevena, Čančar Vladimir, Rodić Milan   +7 more
doaj   +1 more source

Edge Information‐Augmented Auxiliary Diagnosis Method for Cervical Cancer in Medical Decision‐Making Systems

Advanced Intelligent Systems, EarlyView.
To address the problems of insufficient utilization of multiscale features and inefficient feature sharing between tasks in the model, this study proposes an edge‐enhanced intelligent cervical cancer screening method that achieves feature reuse and improves efficiency by jointly optimizing nucleolus segmentation and lesion classification.
Li Wen, Xiaoqing Zhang, Tingyi Dai, Fangfang Gou, Jia Wu   +4 more
wiley   +1 more source

Uterine Tumor Resembling Ovarian Sex Cord Tumors Type II with Vaginal Vault Recurrence

Case Reports in Obstetrics and Gynecology, 2019
UTROSCTs (Uterine Tumors Resembling Ovarian Sex Cord Tumors) are rare neoplasms of unknown etiology usually occurring in middle-aged women. Less than 100 cases of UTROSCT have been reported so far.
Oriana Marrucci, Paola Nicoletti, Alessandro Mauriello, Simone Facchetti, Lodovico Patrizi, Carlo Ticconi, Francesco Sesti, Emilio Piccione   +7 more
doaj   +1 more source

Uterine Neoplasms in 36 Rabbits.

Japanese Journal of Veterinary Anesthesia & Surgery, 2002
動物病院に来院し, 子宮腫瘍と診断された36例のウサギについて検討した。主訴として陰部からの出血が最も多く, また食欲不振や乳腺の腫脹なども多く認められた。診断には, 尿の血液反応, 腹部の触診と乳腺の観察, そして腹部超音波検査が有用であった。腫瘍は腺腫や腺癌が多数を占め, これらは比較的若齢のうちに発生することも多かった。術後短期間の転帰は腫瘍の種類によるよりもむしろ術前の全身状態によるところが大きいものと思われた。早期の発見と適切な外科手術が行われる場合には予後は比較的良好であるが, むしろ若齢時の避妊手術が予防のために有意義であるものと思われた。
Osamu SUNEYA, Junko TERAO, Satoko SHIGA, Makiko NAKANISHI, Masayo TAGAWA, Chiaki MORI, Kumiko SAITO   +6 more
openaire   +2 more sources