Results 211 to 220 of about 598,872 (375)

The Role of CA125 and HE4 in Uterine Sarcomas: Beyond Diagnosis and Prognosis-A Systematic Review and Case Series from a Single Institution. [PDF]

open access: yesCancers (Basel)
Cundari GB   +10 more
europepmc   +1 more source

Connexin43 Promotes the Invasion and Metastasis of Lung Squamous Cell Carcinoma via GJIC‐Dependent Ca2+/ERK Signaling Activation

open access: yesCancer Science, EarlyView.
Cx43 mediated GJIC‐dependent delivery of second messenger Ca2+ thus activating the ERK signaling pathway. Verapamil, effective effectively inhibits these pathways. ABSTRACT Lung squamous cell carcinoma (LUSC) is an extremely metastatic cancer with limited available treatment and poor outcomes.
Xiaocheng Mo   +14 more
wiley   +1 more source

Polarity Gene PARD6B Promotes Tumor Growth of Colorectal Cancer via Increasing MYC Expression

open access: yesCancer Science, EarlyView.
Partitioning Defective 6B (PARD6B), a polarity gene, functions as a scaffold node for the Par protein complex. In this study, we showed that highly expressed PARD6B could promote CRC growth by upregulating MYC expression while suppressing miR‐34c expression.
Kosuke Hirose   +18 more
wiley   +1 more source

PBK Expression Promotes the Aggressive Phenotypes of Mesothelioma

open access: yesCancer Science, EarlyView.
PBK plays a crucial role in cell survival in mesothelioma and is associated with worse outcome. PBK is a promising therapeutic target that may serve as a prognostic biomarker, enabling personalized treatment of mesothelioma. ABSTRACT Mesothelioma is one of the most aggressive neoplasms worldwide that has a particularly poor prognosis.
Kazumi Hori   +12 more
wiley   +1 more source

Epigenetically‐Upregulated CD98 Shed Light on the Precancerous Diagnosis and Prognosis Prediction of Esophageal Cancer

open access: yesCancer Science, EarlyView.
This study confirmed that hypomethylation‐induced upregulation of CD98 promoted ESCC cell proliferation by regulating the cell cycle and was correlated with poorer overall survival of ESCC patients. Combined panels of immunohistochemistry (CD98 and P53) are recommended for accurate diagnosis of esophageal precancerous lesions.
Xue Zhang   +13 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

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