The evolving role of immunotherapy in ovarian cancer
Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani +2 more
wiley +1 more source
Annual Report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2023 and Annual Treatment Report for 2018. [PDF]
Kajiyama H +4 more
europepmc +1 more source
Evidence suggests a potential association between mental health conditions and cancer risk, yet previous studies were limited by small samples and the use of self‐reported measures. Using data from the UK Biobank's large‐scale prospective population cohort over a median follow‐up of 13.4 years, this analysis demonstrates associations between depression,
Mohammed Sherif Amin +8 more
wiley +1 more source
Endometrial Hemangiomatous Polyp Presenting as Postmenopausal Bleeding and Mimicking Uterine Malignancy: A Rare Diagnostic Challenge. [PDF]
Jindal A, Soni A, Kapatia G, Rana MK.
europepmc +1 more source
ABSTRACT Background General pediatricians often evaluate hematologic and oncologic presentations before subspecialty consultation, yet the 2025 Accreditation Council for Graduate Medical Education (ACGME) pediatric requirements reduce inpatient pediatric hematology/oncology (PHO) time, raising questions about resident readiness.
Colburn Yu, Rohini Jain
wiley +1 more source
Giant mucinous ovarian cyst filling the abdominal cavity: clinical presentation, imaging findings, and surgical management. [PDF]
Karakaya H, Gümüş M, Akarsu GD.
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Genetic-Epigenetic Interactions in Uterine Leiomyomas: <i>MED12</i> Mutations as Predictors of Aberrant DNA Methylation. [PDF]
Kazmi T +6 more
europepmc +1 more source
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Exploratory Preoperative Risk Stratification of Uterine Mesenchymal Tumors in Postmenopausal Women with Complementary Transcriptomic Analysis. [PDF]
Wan X +5 more
europepmc +1 more source

