Results 71 to 80 of about 709,987 (360)

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats. [PDF]

, 2017
BackgroundEstrogen deficiency is thought to be responsible for the higher frequency of aneurysmal subarachnoid hemorrhage in post- than premenopausal women.
Hashimoto, Tomoki, Kitazato, Keiko T, Korai, Masaaki, Maekawa, Hidetsugu, Miyamoto, Takeshi, Nagahiro, Shinji, Satomi, Junichiro, Tada, Yoshiteru, Yagi, Kenji   +8 more
core   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Predictors of uterine rupture in a large sample of women in Senegal and Mali: cross-sectional analysis of QUARITE trial data

BMC Pregnancy and Childbirth, 2018
Background The purpose of this study was to investigate predictors of uterine rupture in a large sample of sub-Saharan African women. Uterine rupture is rare in high-income countries, but it is more common in low-income settings where health systems are ...
Rebecca Delafield, Catherine M. Pirkle, Alexandre Dumont   +2 more
doaj   +1 more source

Learning from maternal deaths due to uterine rupture: review of cases from peri-urban UgandaAJOG Global Reports at a Glance

AJOG Global Reports, 2022
BACKGROUND: Maternal deaths from uterine rupture continue to occur globally, with particularly high rates in sub-Saharan Africa. Maternal death reviews have been shown to be an effective part of cohesive strategies to prevent future deaths.
Imelda Namagembe, MD, Sarah M. Chukwuma, MBChB, Annettee Nakimuli, MD, PhD, Noah Kiwanuka, PhD, Josaphat Byamugisha, PhD, Ashley Moffett, MB/BChir, PhD, Catherine E. Aiken, MB/BChir, PhD   +6 more
doaj   +1 more source

A ruptured vulvar labial artery pseudoaneurysm causes a secondary postpartum hemorrhage: A case report. [PDF]

, 2020
Background:Postpartum hemorrhage is the most common cause of maternal morbidity in the United States. However, secondary postpartum hemorrhage is rare and includes pseudoaneurysms, which represent only 3.3% of all cases of secondary postpartum hemorrhage.
Lane, Felicia, Leaf, Marie-Claire, Schmidt, Luke, Serna-Gallegos, Tasha   +3 more
core  

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Uterine Sacculation on Point-of-care Ultrasound in a Pregnant Female Patient: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2022
Introduction: Uterine rupture is a rare but potentially fatal complication of pregnancy. The incidence of uterine rupture is estimated to be between 0.3 and 11 per 10,000.
Ajay Puri, Hersimran Kaur, Zhanna Roit, Mathew Nelson   +3 more
doaj   +1 more source

Internet information on birth options after caesarean compared to the RCOG patient information leaflet : a web survey [PDF]

, 2014
Peer reviewedPublisher ...
Bhattacharya, Siladitya, Black, Mairead, McLernon, David, Whitelaw, Natalie   +3 more
core   +4 more sources

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source