Results 41 to 50 of about 371,169 (260)

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

open access: yesAdvanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma   +18 more
wiley   +1 more source

An Atypical Case of Pelvic Leiomyomatosis Peritonealis Disseminata [PDF]

open access: yes, 2010
An exceptional case of Leiomyomatosis peritonealis disseminata which occurred in a perimenopausal woman was mistaken for ovarian malignancy at laparotomy as it had extensive involvement of the pelvic peritoneum without a trace of leiomyoma in uterus and ...
Bhattacharya, S   +3 more
core  

Gentle Label‐Free Nonlinear Optical Imaging Relaxes Linear‐Absorption‐Mediated Triplet

open access: yesAdvanced Science, EarlyView.
The phototoxicity in nonlinear optical microscopy arises mainly from linear absorption of intrinsic biomolecules rather than nonlinear absorption. This mechanism is supported by a reproducible phototoxicity assay based on widely available chicken breast.
Geng Wang   +4 more
wiley   +1 more source

Hypovolemic shock and hemoperitoneum from spontaneous avulsion of a large pedunculated uterine leiomyoma [PDF]

open access: yes, 2017
Hemoperitoneum with hypovolemic shock from avulsion of a pedunculated leiomyoma is a rare but highly fatal condition that can occur spontaneously or as a result of trauma.
Adamo, Robert   +2 more
core   +2 more sources

Engineered Tissue Models to Decode Host–Microbiota Interactions

open access: yesAdvanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio   +5 more
wiley   +1 more source

Dye diffusion during laparoscopic tubal patency tests may suggest a lymphatic contribution to dissemination in endometriosis: A prospective, observational study [PDF]

open access: yes, 2019
Aim Women with adenomyosis are at higher risk of endometriosis recurrence after surgery. This study was to assess if the lymphatic vessel network drained from the uterus to near organs where endometriosis foci lied.
Bonaccorsi, G.   +6 more
core   +1 more source

PABPN1 Couples the Polyadenylation and Translation of Maternal Transcripts to Mouse Oocyte Meiotic Maturation

open access: yesAdvanced Science, EarlyView.
This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai   +9 more
wiley   +1 more source

SARCOMA OF THE UTERUS. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1902
During the present year a lady 65 years of age came under my care presenting the following history and symptoms. The mother of several children, she had enjoyed good health until about two years ago, when she began to be troubled with constipation and pain in the lower part of abdomen and a sense of weight and pressure in the pelvis.
openaire   +2 more sources

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