Results 141 to 150 of about 82,620 (311)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Quality of experience-aware application deployment in fog computing environments using machine learning. [PDF]

PeerJ Comput Sci
Jenifer P, Angela Jennifa Sujana J.
europepmc   +1 more source

Computed Tomographic Coronary Angiography for Diagnosing Stable Coronary Artery Disease A Cost-Utility and Cost-Effectiveness Analysis

, 2009
Shiori Amemiya, Hidemasa Takao
openalex   +2 more sources

Utility of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in a child with chronic granulomatous disease [PDF]

, 2015
Gunjan Garg, Raphaella DaSilva, Avni Bhalakia, D Milstein   +3 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Editorial: Interdisciplinary synergies in neuroinformatics, cognitive computing, and computational neuroscience. [PDF]

Front Comput Neurosci
Deb N, Khan Z, Sulaiman M, Abu Bakar M.
europepmc   +1 more source

Optimizing User's Utility from Cloud Computing Services in a Networked Environment [PDF]

, 2015
Eli Weintraub, Yuval Cohen
openalex   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Stereo-cell: Advancing spatial single-cell biology towards clinical translation. [PDF]

Clin Transl Med
Baumgartner C.
europepmc   +1 more source

Utility of the computed tomography indices on cone beam computed tomography images in the diagnosis of osteoporosis in women

, 2011
Kwang-Joon Koh, Kyoung-A Kim
openalex   +1 more source