Results 171 to 180 of about 798,436 (334)

Advantages of imperfect dice rolls over coin flips for random number generation. [PDF]

Sci Rep
Pfeffer DT, Allemang CR, Misra S, Severa W, Smith JD.   +4 more
europepmc   +1 more source

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

FEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming‐Yuen Lee, Ratan K. Chaudhuri, Krzysztof Bojanowski   +5 more
wiley   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Quantum machine learning for Lyapunov-stabilized computation offloading in next-generation MEC networks. [PDF]

Sci Rep
Verma VR, Nishad DK, Sharma V, Singh VK, Verma A, Shah DR.   +5 more
europepmc   +1 more source

Computed Tomographic Coronary Angiography for Diagnosing Stable Coronary Artery Disease A Cost-Utility and Cost-Effectiveness Analysis

, 2009
Shiori Amemiya, Hidemasa Takao
openalex   +2 more sources

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Using the properties of the odds ratio to improve precision in meta-analysis: an update on the benefits of targeted deployment of physician-led interprofessional pre-hospital teams on the care of critically ill and injured patients. [PDF]

Scand J Trauma Resusc Emerg Med
McHenry RD.
europepmc   +1 more source

Utility of Nongated Multidetector Computed Tomography for Detection of Left Atrial Thrombus in Patients Undergoing Catheter Ablation of Atrial Fibrillation

, 2009
Matthew W. Martinez, Jacobo Kirsch, Eric E. Williamson, Imran S. Syed, DaLi Feng, Steve R. Ommen, Douglas L. Packer, Peter A. Brady   +7 more
openalex   +1 more source

Utility of Chest Computed Tomography after a “Normal” Chest Radiograph in Patients with Thoracic Stab Wounds [PDF]

, 2015
Brian Nguyen, David Plurad, Sadaf Abrishami, Angela Neville, Brant Putnam, Dennis Y. Kim   +5 more
openalex   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source