Results 31 to 40 of about 798,436 (334)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Geographical Area Network—Structural Health Monitoring Utility Computing Model

ISPRS International Journal of Geo-Information, 2019
In view of intensified disasters and fatalities caused by natural phenomena and geographical expansion, there is a pressing need for a more effective environment logging for a better management and urban planning.
Hasan Tariq, Anas Tahir, Farid Touati, Mohammed Abdulla E. Al-Hitmi, Damiano Crescini, Adel Ben Manouer   +5 more
doaj   +1 more source

Totally-ordered Sequential Rules for Utility Maximization [PDF]

arXiv, 2022
High utility sequential pattern mining (HUSPM) is a significant and valuable activity in knowledge discovery and data analytics with many real-world applications. In some cases, HUSPM can not provide an excellent measure to predict what will happen. High utility sequential rule mining (HUSRM) discovers high utility and high confidence sequential rules,
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Cluster management of computing resources

MATEC Web of Conferences, 2016
The study suggests management of computing resources through set-theoretic clustering. The research proposes production modelling of knowledge — rules of managing explicit and fuzzy structures, according to their technical specifications: sustem ...
Ruchkin V.N., Makhmudov M.N., Romanchuk V.A., Fulin V.A., Kostrov B.V.   +4 more
doaj   +1 more source

Utility-Centric Service Provisioning in Multi-Access Edge Computing

Applied Sciences, 2019
Recently, multi-access edge computing (MEC) is a promising paradigm to offer resource-intensive and latency-sensitive services for IoT devices by pushing computing functionalities away from the core cloud to the edge of networks.
Xuan-Qui Pham, Tien-Dung Nguyen, VanDung Nguyen, Eui-Nam Huh   +3 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Users' experience matter: Delay sensitivity-aware computation offloading in mobile edge computing

Digital Communications and Networks, 2022
As a promising computing paradigm, Mobile Edge Computing (MEC) provides communication and computing capability at the edge of the network to address the concerns of massive computation requirements, constrained battery capacity and limited bandwidth of ...
Mingzhi Wang, Tao Wu, Tao Ma, Xiaochen Fan, Mingxing Ke   +4 more
doaj  

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

A Budget Constraint Incentive Mechanism Based on Risk Preferences of Collaborators in Edge Computing

Mathematics
Mobile Edge Computing (MEC) is a new distributed computing method based on the mobile communication network. It can provide cloud services and an IT service environment for application developers and service providers at the edge of the network ...
Deng Li, Rongtao Hao, Zhenyan Wei, Jiaqi Liu   +3 more
doaj   +1 more source