Results 61 to 70 of about 3,744,885 (347)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

THE CLOUD TECHNOLOGIES OF LEARNING: ORIGIN

Інформаційні технології і засоби навчання, 2015
The research goal is to investigate the evolution of the concept of utility computing in the works of foreign researchers in the years 1959-1966. First the A. O. Mann’s results and expanded overview of the D. F.
Oksana M. Markova, Serhiy O. Semerikov, Andrii M. Striuk   +2 more
doaj  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A Reinforcement Learning-Based Resource Allocation Scheme for Cloud Robotics

IEEE Access, 2018
In recent years, robotic systems combined with cloud computing capability have become an emerging topic of discussion in academic fields. The concept of cloud robotics allows the system to offload computing-intensive tasks from the robots to the cloud ...
Hang Liu, Shiwen Liu, Kan Zheng
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Research on MEC computing offload strategy for joint optimization of delay and energy consumption

Mathematical Biosciences and Engineering
The decision-making process for computational offloading is a critical aspect of mobile edge computing, and various offloading decision strategies are strongly linked to the calculated latency and energy consumption of the mobile edge computing system ...
Mingchang Ni , Guo Zhang , Qi Yang, Liqiong Yin   +3 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Prognostic utility of the chest computed tomography severity score for the requirement of mechanical ventilation and mortality in hospitalized patients with COVID-19 [PDF]

, 2023
Yukiyoshi Kimura, César Cristancho-Rojas, Yumi Kimura-Sandoval, Ramiro Tapia-Sosa, Lorena Guerrero‐Torres, Mariana Licano-Zubiate, Mónica Chapa-Ibargüengoitia   +6 more
openalex   +1 more source

Optimizing virtual machine placement for energy and SLA in clouds using utility functions

Journal of Cloud Computing: Advances, Systems and Applications, 2016
Cloud computing provides on-demand access to a shared pool of computing resources, which enables organizations to outsource their IT infrastructure.
Abdelkhalik Mosa, Norman W. Paton
doaj   +1 more source