Results 211 to 220 of about 2,079,957 (313)

The utilization, characteristics, and influencing factors of non-therapeutic traditional Chinese medicine services among middle-aged and older population in Guangzhou, China: a cross-sectional study. [PDF]

Front Public Health
Ren J, Hao J, Jia Z, Zheng C, Zheng Y, Wu Z, Zhou X, Wu H, Ye X, Ma X, Lin B, Yang L.   +11 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Male partner involvement in ANC to increase institutional delivery and postnatal care utilization in developing countries: a systematic review and meta-analysis. [PDF]

BMC Health Serv Res
Baykemagn FT, Berhane F, Gebrezgiabher G, Gebregergs GB, Aregay H, Debesay MH, Gebregziabher Y, Asmelash H, Hagos T, Tezera D, Hadgu D, Berhe G, Gidey G, Kidanemariam A, Tesfau YB, Milner N.   +15 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Zero-inflated negative binomial modelling of antenatal care utilization and it's predictors in Somaliland: <i>evidence from the 2020 demographic and health survey</i>. [PDF]

Front Glob Womens Health
Guled AM, Nuh AM, Mohamed MA, Mohamed RA, Muse AH, Ali HA, Abdi HA.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Utilization of Information Communication Technology and Its Associated Factors Among Healthcare Professionals: Systematic Review and Meta-Analysis, in the Resource-Limited Setting. [PDF]

Biomed Res Int
Shibabaw AA, Butta FW, Chereka AA, Gebreariam YH, Kitil GW, Mamo DN.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Implementing the Lung Donor (LUNDON) acceptability score in U.S. donor management and transplant decision-making: A multi-aim, mixed-methods protocol. [PDF]

PLoS One
Rossetti NE, Morrison S, Chang SH, Yan Y, Jaensch-Frie G, Liu CR, Seyoum NY, Katta M, Kumar A, Yang Z, Oncken C, Hamilton C, Schroy N, Stumbaugh K, Marklin G, Heiden B, Cummiskey B, Peskoe S, Hartwig M, Puri V, Baumann AA.   +20 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source