Results 91 to 100 of about 7,866 (244)

Cytokine Engineering Approaches for Regenerative Medicine

Advanced Therapeutics, Volume 8, Issue 9, September 2025.
Engineered cytokines represent a powerful strategy to promote tissue repair and regeneration by precisely modulating immune responses. This review highlights recent advances in cytokine engineering, including strategies to enhance half‐life, improve tissue and cell targeting, and control receptor signaling.
Shiyi Li, Wenhao You, Mikaël M. Martino
wiley   +1 more source

Utrophin localization in normal and dystrophin-deficient heart. [PDF]

Circulation, 1994
BACKGROUND The localization of dystrophin at the sarcolemma of cardiac skeletal fibers and cardiac Purkinje fibers has been described. Dystrophin deficiency produces clinical manifestations of disease in skeletal muscles and hearts of patients with Duchenne and Becker muscular dystrophy. Utrophin (or dystrophin-related protein),
Pons, Françoise, Robert, Agnès, Fabbrizio, Eric, Hugon, Gerald, Califano, Jean-Christophe, Fehrentz, Jean-Alain, Martinez, Jean, Mornet, Dominique   +7 more
openaire   +3 more sources

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Functional characterisation of filamentous actin probe expression in neuronal cells. [PDF]

PLoS ONE, 2017
Genetically encoded filamentous actin probes, Lifeact, Utrophin and F-tractin, are used as tools to label the actin cytoskeleton. Recent evidence in several different cell types indicates that these probes can cause changes in filamentous actin dynamics,
Shrujna Patel, Sandra Y Y Fok, Holly Stefen, Tamara Tomanić, Esmeralda Parić, Rosanna Herold, Merryn Brettle, Aleksandra Djordjevic, Thomas Fath   +8 more
doaj   +1 more source

Utrophin Transcription Is Activated by an Intronic Enhancer [PDF]

Journal of Biological Chemistry, 2000
The utrophin gene codes for a large cytoskeletal protein closely related to dystrophin. Its transcription is driven by a TATA-less promoter. Here we analyzed 40 kilobases of the 5' end region of the utrophin gene searching for new utrophin regulatory elements in muscle cells.
GALVAGNI F., OLIVIERO, Salvatore
openaire   +5 more sources

Incidence and Immunopathology of Myositis in Rectal Cancer Patients Treated With Neoadjuvant Immune Checkpoint Inhibitors and Chemoradiotherapy: Findings From the CHINOREC Trial

MedComm, Volume 6, Issue 7, July 2025.
ICI‐induced myositis occurred at a higher‐than‐expected rate (12%) in neoadjuvant‐treated rectal cancer patients receiving CRT+ICI. Elevated cTnT, but not cTnI, differentiated skeletal from cardiac involvement. Immunopathology showed a predominant CD8+ T cell infiltrate, highlighting a T cell‐mediated mechanism that necessitates early detection and ...
Rebecca Zirnbauer, Simon Hametner, Jutta Bergler‐Klein, Irene Kuehrer, Askin Kulu, Daphni Ammon, Julijan Kabiljo, Anton Stift, Rainer Schmid, Leonhard Müllauer, Clemens Bittermann, Friedrich Laengle, Klaus Machold, Stephan Blüml, Michael Bergmann, Johannes Laengle   +15 more
wiley   +1 more source

Skeletal muscle-specific ablation of gamma(cyto)-actin does not exacerbate the mdx phenotype.

PLoS ONE, 2008
We previously documented a ten-fold increase in gamma(cyto)-actin expression in dystrophin-deficient skeletal muscle and hypothesized that increased gamma(cyto)-actin expression may participate in an adaptive cytoskeletal remodeling response.
Kurt W Prins, Dawn A Lowe, James M Ervasti   +2 more
doaj   +1 more source

Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin [PDF]

, 2014
Background: Duchenne muscle dystrophy (DMD) afflicts 1 million boys in the US and has few effective treatments. Constitutive transgenic expression of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α ...
Arany, Zolt, Chan, Mun Chun, Farrell, Caitlin, Patten, Ian S, Raghuram, Srilatha, Rowe, Glenn C   +5 more
core   +1 more source

Obligatory and accessory respiratory muscle structure, function and control in early and advanced disease in the mdx mouse model of Duchenne muscular dystrophy

The Journal of Physiology, Volume 603, Issue 14, Page 4113-4152, 15 July 2025.
Abstract figure legend We examined obligatory (diaphragm, external intercostal and parasternal) and accessory (sternomastoid, cleidomastoid, scalene and trapezius) muscle form, function and control in early (4 months) and advanced (16 months) dystrophic disease. Peak inspiratory pressure is preserved in 4‐month‐old mdx mice but is decreased in 16‐month‐
Aoife D. Slyne, David P. Burns, Karina Wöller, Amandine May, Roisin Dowd, Sarah E. Drummond, Grzegorz Jasionek, Ken D. O'Halloran   +7 more
wiley   +1 more source

Utrophin up-regulation by an artificial transcription factor in transgenic mice.

PLoS ONE, 2007
Duchenne Muscular Dystrophy (DMD) is a severe muscle degenerative disease, due to absence of dystrophin. There is currently no effective treatment for DMD.
Elisabetta Mattei, Nicoletta Corbi, Maria Grazia Di Certo, Georgios Strimpakos, Cinzia Severini, Annalisa Onori, Agata Desantis, Valentina Libri, Serena Buontempo, Aristide Floridi, Maurizio Fanciulli, Dilair Baban, Kay E Davies, Claudio Passananti   +13 more
doaj   +1 more source