Results 11 to 20 of about 7,812 (251)

Translational regulation of utrophin by miRNAs. [PDF]

PLoS ONE, 2011
BackgroundUtrophin is the autosomal homolog of dystrophin, the product of the Duchenne Muscular Dystrophy (DMD) locus. Its regulation is of therapeutic interest as its overexpression can compensate for dystrophin's absence in animal models of DMD.
Utpal Basu, Olga Lozynska, Catherine Moorwood, Gopal Patel, Steve D Wilton, Tejvir S Khurana   +5 more
doaj   +5 more sources

Dystrophin and utrophin: the missing links! [PDF]

FEBS Letters, 1995
There is considerable sequence homology between dystrophin and utrophin, both at the protein and DNA level, and consequently it was assumed that their domain structures and functions would be similar. As more of the detailed biochemical and cell biological properties of these two proteins become known, so it becomes clear that there are subtle if not ...
Steven J. Winder, Toby J. Gibson, John Kendrick-Jones   +2 more
openaire   +4 more sources

Utrophin: A Structural and Functional Comparison to Dystrophin [PDF]

Brain Pathology, 1996
Utrophin is an autosomally‐encoded homologue of dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene. Although, Utrophin is very similar in sequence to dystrophin and possesses many of the protein‐binding properties ascribed to dystrophin, both proteins are expressed in an apparently reciprocal manner and may be coordinately ...
Derek J. Blake, Jonathon M. Tinsley, Kay E. Davies   +2 more
openalex   +4 more sources

Disruption of the utrophin‒actin interaction by monoclonal antibodies and prediction of an actin-binding surface of utrophin [PDF]

Biochemical Journal, 1999
Monoclonal antibody (mAb) binding sites in the N-terminal actin-binding domain of utrophin have been identified using phage-displayed peptide libraries, and the mAbs have been used to probe functional regions of utrophin involved in actin binding. mAbs were characterized for their ability to interact with the utrophin actin-binding domain and to affect
Glenn E. Morris, Nguyen thi Mân, Nguyen thi Ngoc HUYEN, Alexander PEREBOEV, John Kendrick‐Jones, Steven J. Winder   +5 more
openalex   +3 more sources

Association of Aciculin with Dystrophin and Utrophin [PDF]

Journal of Biological Chemistry, 1995
Aciculin is a recently identified 60-kDa cytoskeletal protein, highly homologous to the glycolytic enzyme phosphoglucomutase type 1, (Belkin, A. M., Klimanskaya, I. V., Lukashev, M. E., Lilley, K., Critchley, D., and Koteliansky, V. E. (1994) J. Cell Sci. 107, 159-173).
Alexey M. Belkin, Keith Burridge
openalex   +5 more sources

Sticky utrophin messages

The Journal of Cell Biology, 2001
![Graphic][1] Utrophin mRNAs bind to actin. On [page 1173][2], Gramolini et al. report that utrophin mRNA is immobilized by binding to an actin-dependent structure. Manipulation of this system may be important for the therapy of Duchenne muscular dystrophy (DMD).
William A. Wells
openalex   +4 more sources

Fatigue Resistance and Mitochondrial Adaptations to Isometric Interval Training in Dystrophin-Deficient Muscle: Role of Contractile Load. [PDF]

FASEB J
High‐load, but not low‐load, isometric interval training (IT) increased mitochondrial content and muscle fatigue resistance in mdx52 mice, a model for Duchenne muscular dystrophy. High‐load isometric IT restored citrate synthase activity, peroxisome proliferator‐activated receptor γ coactivator 1 alpha (PGC‐1α) expression, and mitochondrial complex II ...
Yamauchi N, Ashida Y, Naito A, Tokuda N, Niibori A, Motohashi N, Aoki Y, Yamada T.   +7 more
europepmc   +2 more sources

Human dystrophin tandem calponin homology actin-binding domain crystallized in a closed-state conformation. [PDF]

Acta Crystallogr D Struct Biol
The structure of the N‐terminal actin‐binding domain of human dystrophin was determined, revealing a closed conformation with the first and second calponin homology domains directly interacting.The structure of the N‐terminal actin‐binding domain of human dystrophin was determined at 1.94 Å resolution.
Streeter O, Shi K, Vavra J, Aihara H, Ervasti JM, Evans R, Muretta JM.   +6 more
europepmc   +2 more sources

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

IRES-mediated translation of utrophin A is enhanced by glucocorticoid treatment in skeletal muscle cells. [PDF]

PLoS ONE, 2008
Glucocorticoids are currently the only drug treatment recognized to benefit Duchenne muscular dystrophy (DMD) patients. The nature of the mechanisms underlying the beneficial effects remains incompletely understood but may involve an increase in the ...
Pedro Miura, Meghan Andrews, Martin Holcik, Bernard J Jasmin   +3 more
doaj   +1 more source