Results 61 to 70 of about 7,812 (251)
Role of dystrophins and utrophins in platelet adhesion process [PDF]
British Journal of Haematology, 2006 SummaryPlatelets are crucial at the site of vascular injury, adhering to the sub‐endothelial matrix through receptors on their surface, leading to cell activation and aggregation to form a haemostatic plug. Platelets display focal adhesions as well as stress fibres to contract and facilitate expulsion of growth and pro‐coagulant factors contained in ...
Ricardo Mondragón +5 more
openaire +3 more sources
Contribution of the different modules in the utrophin carboxy-terminal region to the formation and regulation of the DAP complex [PDF]
, 2000 The carboxy-terminal region of utrophin, like the homologous proteins dystrophin, Drp2 and dystrobrevins, contains structural domains frequently involved in protein–protein interaction.
Cesareni, Gianni +4 more
core +1 more source
The FEBS Journal, EarlyView.A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley +1 more source
Microtubule binding distinguishes dystrophin from utrophin [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Our in vitro analyses reveal that dystrophin, the protein absent in Duchenne muscular dystrophy patients, binds microtubules with high affinity and pauses microtubule polymerization, whereas utrophin, the autosomal homologue of dystrophin thought to mirror many known functions of dystrophin, has no activity in either assay.
Michael D. Eckhoff +7 more
openaire +3 more sources
Steric regulation of tandem calponin homology domain actin-binding affinity. [PDF]
, 2019 Tandem calponin homology (CH1-CH2) domains are common actin-binding domains in proteins that interact with and organize the actin cytoskeleton. Despite regions of high sequence similarity, CH1-CH2 domains can have remarkably different actin-binding ...
Bausch, Andreas +6 more
core +1 more source
Drp2 and Periaxin Form Cajal Bands with Dystroglycan But Have Distinct Roles in Schwann Cell Growth [PDF]
, 2012 Cajal bands are cytoplasmic channels flanked by appositions where the abaxonal surface of Schwann cell myelin apposes and adheres to the overlying plasma membrane.
Brophy, Peter J. +4 more
core +1 more source
PLoS Genetics, 2020 Gene therapy approaches for DMD using recombinant adeno-associated viral (rAAV) vectors to deliver miniaturized (or micro) dystrophin genes to striated muscles have shown significant progress.
Glen B Banks +2 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend We examined obligatory (diaphragm, external intercostal and parasternal) and accessory (sternomastoid, cleidomastoid, scalene and trapezius) muscle form, function and control in early (4 months) and advanced (16 months) dystrophic disease. Peak inspiratory pressure is preserved in 4‐month‐old mdx mice but is decreased in 16‐month‐
Aoife D. Slyne +7 more
wiley +1 more source
Genome Editing-Mediated Utrophin Upregulation in Duchenne Muscular Dystrophy Stem Cells
Molecular Therapy: Nucleic Acids, 2020 Utrophin upregulation is considered a promising therapeutic strategy for Duchenne muscular dystrophy (DMD). A number of microRNAs (miRNAs) post-transcriptionally regulate utrophin expression by binding their cognate sites in the 3′ UTR.
Kasturi Sengupta +5 more
doaj
MedComm, Volume 6, Issue 7, July 2025.ICI‐induced myositis occurred at a higher‐than‐expected rate (12%) in neoadjuvant‐treated rectal cancer patients receiving CRT+ICI. Elevated cTnT, but not cTnI, differentiated skeletal from cardiac involvement. Immunopathology showed a predominant CD8+ T cell infiltrate, highlighting a T cell‐mediated mechanism that necessitates early detection and ...
Rebecca Zirnbauer +15 more
wiley +1 more source