Results 41 to 50 of about 14,210 (240)

Efficacy and Safety of Adalimumab in Pediatric Non-infectious Non-anterior Uveitis: Real-life Experience From the International AIDA Network Uveitis Registry

Ophthalmology and Therapy, 2023
Introduction Scientific evidence of the effectiveness of the tumor necrosis factor inhibitor adalimumab (ADA) in pediatric patients with non-infectious non-anterior uveitis is still limited. The aim of this study is to investigate the therapeutic role of
Antonio Vitale, Francesca Della Casa, Silvana Guerriero, Gaafar Ragab, Angela Mauro, Valeria Caggiano, Marco Cattalini, Emanuela Del Giudice, Rossella Favale, Carla Gaggiano, Irene Bellicini, Maria Pia Paroli, Mohamed Tharwat Hegazy, Jurgen Sota, Abdurrahman Tufan, Alberto Balistreri, Ibrahim Almaghlouth, Francesco La Torre, Ewa Więsik-Szewczyk, Maria Tarsia, Andrea Hinojosa-Azaola, Eduardo Martín-Nares, Bruno Frediani, Gian Marco Tosi, Alex Fonollosa, José Hernández-Rodríguez, Rana Hussein Amin, Giuseppe Lopalco, Donato Rigante, Luca Cantarini, Claudia Fabiani   +30 more
doaj   +1 more source

Granuloma de coróide secundário a membrana neovascular sub-retiniana em uveíte intermediária: relato de casos [PDF]

, 2008
Choroidal neovascularization is a very rare complication in intermediate uveitis. A 27-year-old female patient diagnosed with intermediate uveitis two years ago.
Garcia Filho, Carlos Alexandre de Amorim, Garcia, Ana Cláudia Medeiros de Amorim, Garcia, Carlos Alexandre de Amorim, Segundo, Paulo de Souza   +3 more
core   +2 more sources

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Relationship of the ocular surface temperature with the clinical features of induced non-infectious anterior and intermediate uveitis in rabbits

Journal of Ophthalmology, 2020
Background: It is an important challenge to develop objective methods for assessing intraocular inflammation. Purpose: To assess the relationship of the ocular surface temperature in the projection of the ciliary body with the clinical signs of ...
O. Dorokhova, O. Zborovska, Men Guanjun
doaj   +1 more source

Cytokine Profiles in Toxoplasmic and Viral Uveitis [PDF]

, 2017
BackgroundUveitis is a major cause of visual impairment throughout the world. Analysis of cytokine profiles in aqueous humor specimens may provide insight into the physiopathological processes that underly retinal damage in this context MethodsUsing a ...
Abdelrahman, Tamer, Abou-Bacar, Ahmed, Babba, Hamouda, Ben Yahia, Salim, Bourcier, Tristan, Candolfi, Ermanno, Garweg, Justus G., Guinard, Marie, Kairallah, Moncef, Lahmar, Ibtissem, Mousli, Marc, Pfaff, Alexander W., Sauer, Arnaud, Speeg-Schatz, Claude, Villard, Odile   +14 more
core  

Association between visual function response and reduction of inflammation in noninfectious uveitis of the posterior segment [PDF]

, 2017
PURPOSE. To examine the association between visual function response (VFR) and inflammation reduction in active noninfectious uveitis of the posterior segment (NIU-PS). METHODS.
Bodaghi, Bahram, Duchateau, Luc, Lescrauwaet, Benedicte, Miserocchi, Elisabetta, Srivastava, Sunil, Thurau, Stephan, Verstraeten, Thomas   +6 more
core   +3 more sources

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Retinal S-antigen Th1 cell epitope mapping in patients with Behcet's disease [PDF]

Background - Retinal S-antigen (S-Ag) is a most characterized autoantigen of autoimmune uveitis. The recognized immunodominant epitope of human S-Ag in patients with uveitis has not been identified. In this study, we selected certain patients with active
Du, L.P., He, H., Kijlstra, A., Lin, X.M., Yang, P.Z., Zhao, C.L., Zhou, H.Y.   +6 more
core   +2 more sources

Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]

, 2018
Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Born, Willi K, Kaplan, Henry J, Liang, Dongchun, O'Brien, Rebecca L, Shao, Hui, Sun, Deming, Woo, Jeong-Im   +6 more
core   +3 more sources

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source