Results 61 to 70 of about 13,936 (245)

Inosine triphosphate pyrophosphatase activity as a potential predictor of methotrexate remission in juvenile idiopathic arthritis

Arthritis &Rheumatology, Accepted Article.
Background Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients don't respond. Low inosine‐triphosphate‐pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated ITPA role and the underlying mechanisms in vitro.
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Demography and clinical pattern of newly diagnosed uveitis patients in Malaysia

Journal of Ophthalmic Inflammation and Infection, 2022
Introduction Uveitis is one of the common causes of visual impairment in Malaysia. It remains a challenging entity to diagnose and manage due to variation in its clinical presentation.
Rajasudha Sawri Rajan, Shelina Oli Mohamed, Mohamad Aziz Salowi, Malaysian Uveitis Study Group, Ministry of Health Malaysia   +4 more
doaj   +1 more source

Prevalence, clinical profile, investigations, and visual outcome of sarcoid intermediate uveitis in a tertiary eye care center in South India

Indian Journal of Ophthalmology, 2022
Purpose: To report the prevalence, clinical profile, investigations, and visual outcomes of sarcoid intermediate uveitis in a tertiary eye care center in South India. Methods: Retrospective, observational case series.
Jeyasooriya Ramdoss, Anupreeti Jain, G N Thejesvi, Jyotirmay Biswas   +3 more
doaj   +1 more source

Review of Systemic Immunosuppression for Autoimmune Uveitis [PDF]

, 2014
The purpose of this review is to comprehensively examine the various therapeutic agents available to treat autoimmune eye disease, their indications, clinical safety and recent developments.
Castiblanco, Claudia, Foster, C. Stephen
core   +1 more source

Tissue Damage in Rheumatoid Arthritis is Genetically linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, Accepted Article.
Objectives Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biological mechanism underlying this association. Methods Expression of surrounding genes was compared between rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E Mains, Betty A Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source

Bilateral spontaneous retinal dialysis in multiple sclerosis related intermediate uveitis: Unusual case report

American Journal of Ophthalmology Case Reports
Purpose: To report a case of rhegmatogenous retinal detachment (RRD) caused by spontaneous retinal dialysis in intermediate uveitis due to multiple sclerosis (MS).
Saket Arya, Rehab Sabry Helal, Merlyn Anjali Pereira, Hashem Abu Serhan   +3 more
doaj   +1 more source

Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases

Journal of Immunology Research, 2015
Purpose. Interleukin 6 (IL-6) plays a crucial role in both adaptive and innate immunity. The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis. Methods.
Lindner Ewald, Langner-Wegscheider Beate, Sarny Stephanie, Renner Wilfried, El-Shabrawi Yosuf   +4 more
doaj   +1 more source

Two cases of uveitis masquerade syndrome caused by bilateral intraocular large B-cell lymphoma [PDF]

, 2013
Introduction. Sometimes it is not easy to clinically recognize subtle differences between intraocular lymphoma and noninfectious uveitis. The most common lymphoma subtype involving the eye is B-cell lymphoma. Case report.
Jovanović Svetlana, Jovanović Zorica, Marković Vujica, Paović Jelena, Pešić Snežana, Čeperković-Stanković Vesna   +5 more
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Etiology and Anatomical Location of Uveitis—Prognostic Factors for Disease Course and Laterality

Life
Background: Uveitis encompasses a broad group of diseases with infectious and non-infectious etiologies, potentially leading to permanent and irreversible visual impairment.
Vesela Todorova Mitkova-Hristova, Marin Anguelov Atanassov   +1 more
doaj   +1 more source