LRRK2 G2019S mutation is the most common genetic cause of Parkinson's disease but its contribution to nigrostriatal neurodegeneration, particularly in response to mitochondrial dysfunction, remains unclear. hLRRK2*G2019S transgenic mice exhibited early microglial activation and motor alterations, but not increased dopaminergic nigrostriatal ...
Roberto García‐Swinburn +8 more
wiley +1 more source
[Clinical coordination and strengthening of primary care for cancer diagnosis in Latin America: a scoping reviewCoordenação clínica e fortalecimento da atenção primária no diagnóstico do câncer na América Latina: revisão de escopo]. [PDF]
Luer-Aguila R +3 more
europepmc +1 more source
ABSTRACT Introduction Osteoporosis is a chronic skeletal condition that significantly affects daily life and may benefit from adequate self‐care. The Middle‐Range Theory of Self‐Care of Chronic Illness conceptualizes self‐care as a naturalistic process encompassing maintenance, monitoring, and management, also shaped by contextual and cultural factors.
Chiara Tedesco +14 more
wiley +1 more source
Unilateral Chewing Frequency and Self‐Reported Mastication Satisfaction: A Cross‐Sectional Study
Frequent unilateral chewing is associated with reduced self‐reported mastication satisfaction. The lowest satisfaction was reported among individuals engaging in constant unilateral chewing, independent of demographic and psychological factors. ABSTRACT Objective This study aimed to assess the association between unilateral chewing frequency and self ...
Carlo Ciotola +3 more
wiley +1 more source
Artificial intelligence computed tomography models for the discrimination of Wilms versus non-Wilms tumors: systematic review and meta-analysis. [PDF]
Ardicli B.
europepmc +1 more source
ABSTRACT Controlled studies have demonstrated that light supplementation benefits circadian entrainment, sleep and mood. Translating these findings into effective, real‐world usage of light supplementation is, however, challenging because naturalistic and supplemental light exposure are shaped by personal habits and environmental light conditions ...
Débora B. Constantino +18 more
wiley +1 more source
Danon Disease: Understanding the Role of LAMP2 Variants in Cardiomyopathy and Multisystemic Involvement. [PDF]
Ribeiro GNP +7 more
europepmc +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8724-8728, September 2026.
Juan Manuel Arteaga‐Diaz +4 more
wiley +1 more source
Can an amide analog retain the high potency of the classic urea motif in soluble epoxide hydrolase inhibitors? Through a single unconventional switch, the introduction of the underexplored pentafluorosulfanyl group into an amide analog of TPPU, the authors restored high inhibitory potency.
Alba López‐Ruiz +17 more
wiley +1 more source
[Glycemic control, psychosocial factors, and quality of life among people with diabetes in primary health care settingsControl de la glucemia, factores psicosociales y calidad de vida en personas con diabetes en entornos de atención primaria de salud]. [PDF]
Ribeiro Junior CA +2 more
europepmc +1 more source

