Results 181 to 190 of about 1,983,859 (250)

Arboviruses circulation in Guinea: Overview and perspectives for public health. [PDF]

PLoS Negl Trop Dis
Bangoura ST, Keita AK, Sidibé S, Camara SC, Diaby M, Kadio KJO, Soumah AK, Diallo H, Delamou A, Delaporte E, Camara A, Ottmann M, Khanafer N, Touré A.   +13 more
europepmc   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Pentameric M2e influenza vaccine candidate generates strong immunity with limited survival benefit. [PDF]

Hum Vaccin Immunother
Kumar V, Vishwakarma P, Raj S, Saxena S, Rizvi ZA, Kumar A, Awasthi A, Samal S.   +7 more
europepmc   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection. [PDF]

PLoS Pathog
Watanabe Y, Ibrahim MS, Arai Y, Kuroda D, Elgendy EM, Nakakita SI, Takeda Y, Nghia Bui V, Ono T, Ushiba S, Daidoji T, Sriwilaijaroen N, Ogawa H, Matsumoto K, Suzuki Y, Nakaya T.   +15 more
europepmc   +1 more source

4D Mapping of ZIF Biocomposites for High Protein Loading and Tunable Release Profiles

Advanced Functional Materials, EarlyView.
Systematic four‐dimensional mapping of zeolitic imidazolate framework biocomposites reveals how precursor ratios, total concentration, and washing define crystalline phase, protein loading, and release kinetics. This comprehensive study identifies conditions yielding record loading (∼85%) and precise phase–property correlations.
Michael R. Hafner, Francesco Carraro, Behnaz Abbasgholi‐NA, Simone Dal Zilio, Max Schmallegger, Helmar Wiltsche, Lingcong Ge, Michael R. Reithofer, Efwita Astria, Laura Villanova, Heinz Amenitsch, Christian Doonan, Paolo Falcaro   +12 more
wiley   +1 more source

Development and validation of a sensitive fluorescence RT-qPCR assay with TaqMan-MGB probe for detection of H6 subtype avian influenza A virus. [PDF]

J Vet Diagn Invest
Li X, Tian J, Zhou W, Liu S, Peng C, Li J, Hou G, Yang J, Liu X, Liu H, Jiang W.   +10 more
europepmc   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Lethal Case of Bourbon Virus Leading to Shock and ECMO Utilization. [PDF]

Case Rep Infect Dis
Mitchell A, Gessouroun A, Atrouni WE, Kubat R, Almoghrabi O, Vorhies M, Flynn B.   +6 more
europepmc   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source