Results 161 to 170 of about 7,510,342 (308)

The structural and functional significance of lipid-binding properties of human Notch ligands

open access: yes
The Notch receptor and its canonical ligands Jagged/Serrate and Delta-like form part of a core metazoan juxtacrine signal transduction pathway crucial for development and tissue homeostasis.
Feng, Xinyi
core   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

open access: yesAdvanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu   +14 more
wiley   +1 more source

Study of the plastic zone size in the V-notch tip vicinity

open access: yes, 2000
A plastic zone at a sharp V-notch tip is studied in this paper. Relation for the plastic zone shape and size of a V-notch loaded by mode I in dependence on the open angle 2 alpha of a V-notch is derived.
Klusák, Jan
core  

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

open access: yesAdvanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv   +8 more
wiley   +1 more source

Architected Inverse Nacre Hydrogels With High Strength and Crack‐Insensitive Toughness

open access: yesAdvanced Science, EarlyView.
Hydrogels hold promise for biomedical and engineering applications, yet their practical use is fundamentally limited by the strength‐toughness trade‐off and poor fatigue resistance. In this study, a bioinspired inverse nacre architecture constructed via a scalable thermo‐calendering process is introduced, which overcomes these classic limitations ...
Haidi Wu   +10 more
wiley   +1 more source

A model for estimation of threshold values V-notch emanating fatigue cracks

open access: yes, 2000
Threshold values for V-notch emanating fatigue cracks are expressed by means of threshold value for high cyclic fatigue crack propagation and the open angle of a V-notch.
Klusák, Jan
core  

Oral Motion‐Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect

open access: yesAdvanced Science, EarlyView.
We proposed a method based on the piezoelectric effect and fabricated an implant abutment on the basis of piezoelectric ceramic. Under physiological occlusal pressure, the oral motion‐powered smart dental implant abutments interacted with water and oxygen, promoting the formation of reactive oxygen species and achieving a synergistic and highly ...
Xiyu Shi   +15 more
wiley   +1 more source

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