Results 161 to 170 of about 9,951,210 (253)

Bio-Inspired Internal Stress Engineering for Microscale Surface Cracking in Sensitive Strain Sensors. [PDF]

Adv Sci (Weinh)
This study presents a bio‐inspired internal stress engineering strategy to fabricate highly sensitive crack‐based strain sensors. By harnessing the internal expansion energy of microspheres and the thickness‐dependent brittle‐to‐ductile transition of ultrathin gold films, tunable microscale cracks are generated.
Jang JY, Cho H, Jung Y.
europepmc   +2 more sources

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

Targeting mannosylation of nicastrin N-glycans attenuates γ-secretase activity and notch-dependent leukemia progression. [PDF]

J Clin Invest
Jiang H, Bian W, Cao Y, Zhang Z, Chen Y, Sui Y, Qin H, Li X.   +7 more
europepmc   +1 more source

Anatomical features of suprascapular notch: correlation with scapular dimension and clinical relevance.

, 2012
Introduction An improved knowledge of the suprascapular notch anatomy may help to prevent and to well-assess the suprascapular nerve entrapment syndrome.
V. Arceri, GUMINA, STEFANO, V. Candela, D. Passaretti, P. Albino, S. Carbone   +5 more
core  

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Pan-cancer analysis of Notch pathway-linked gene expression identifies tumour-specific and sex-stratified prognostic associations. [PDF]

Clin Transl Radiat Oncol
O'Hea H, Bourbonne V, Marignol L.
europepmc   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Notch-mediated lateral inhibition is shaped by morphological differences to reinforce bias toward signal-sending or -receiving roles. [PDF]

Curr Biol
Richa P, Roussos C, Zhu C, Lenz MO, Kasirer S, Sprinzak D, Bray SJ.   +6 more
europepmc   +1 more source

Modified Proportional V-Notch Weirs

, 1978
Seven different shaped modified proportional V-notches were designed and pertinent data for their use are given in tables 1 - 4. It is shown that the indication accuracies of these weirs are more than that of the conventional V-notch.
Murthy, Keshava K, Pillai, Gopalakrishna K   +1 more
core  

Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates

Advanced Science, EarlyView.
Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta, Julien Duclay, Robin Baurès, Andrea Alamia   +3 more
wiley   +1 more source