Results 71 to 80 of about 9,737,503 (211)

Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning

open access: yesAdvanced Science, EarlyView.
SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

open access: yesAdvanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon   +6 more
wiley   +1 more source

Post-COVID-19 condition: a sex-based analysis of clinical and laboratory trends

open access: yesFrontiers in Medicine
Background and aimPost-COVID-19 condition (PCC) encompasses long-lasting symptoms in individuals with COVID-19 and is estimated to affect between 31–67% of patients, with women being more commonly affected.
Carlos Delfino   +16 more
doaj   +1 more source

Deep Learning Prediction of O‐Glycopeptide Tandem Mass Spectra Enhances O‐Glycoproteomics

open access: yesAdvanced Science, EarlyView.
DeepGPO integrates Transformer and graph neural networks with tailored training strategies, including data augmentation, loss re‐weighting, and pre‐training, to achieve high‐quality O‐glycopeptide MS/MS spectra prediction. The predicted MS/MS spectra are used to localize O‐glycosylation sites from HCD MS/MS data, enhancing O‐glycoproteomics analysis ...
Yu Zong, Yuxin Wang, Liang Qiao
wiley   +1 more source

Core components of male-specific person-centred HIV care: a qualitative analysis from client and healthcare worker perspectives in Malawi

open access: yesBMJ Public Health
Introduction Person-centred care (PCC) improves clinical outcomes for people living with HIV. Heterosexual men in sub-Saharan Africa are under-represented in HIV care, yet PCC interventions for men are lacking.
Sam Phiri   +11 more
doaj   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

open access: yesAdvanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long   +12 more
wiley   +1 more source

Effects of Rbp3 on lipid peroxidation and salt tolerance in Synechocystis sp PCC 6803

open access: yes, 2013
RNA-binding proteins (Rbps) are involved in many post-transcriptional regulation processes. As previously shown, inactivation of rbp3 in Synechocystis sp.
Xu, XD (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China.   +2 more
core   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

open access: yesAdvanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song   +9 more
wiley   +1 more source

uvgVPCCenc: Practical Open-Source Encoder for Fast V-PCC Compression

open access: yes
Video-based Point Cloud Compression (V-PCC) standard offers state-of-the-art tools and efficiency for volumetric video compression. The V-PCC reference software, TMC2, is able to demonstrate the compression efficiency of V-PCC, but with computational ...
Fréneau, Louis   +3 more
core   +1 more source

Real-time assessment of PV-DSTATCOM for grid power quality enhancement using an indirect current control strategy

open access: yesScientific Reports
This paper presents a real-time simulation of a photovoltaic-based distribution static compensator (PV-DSTATCOM) using the Typhoon HIL 604 simulator, demonstrating its effectiveness in reactive power compensation, harmonic mitigation, and active power ...
Vinamra Kumar Govil   +2 more
doaj   +1 more source

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