Results 51 to 60 of about 326,565 (290)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Urban vacancy: mapping the European research landscape

European Journal of Spatial Development
Although still a niche within established disciplines, research on urban vacancy has boomed in recent decades, with different research communities investigating different dimensions of vacancy.
Bas van Heur
doaj   +1 more source

Influence of Th, Zr, and Ti Dopants on Solution Property of Xe in Uranium Dioxide with Defects: A DFT + U Study

Metals, 2022
To ensure the safety and efficient operation of nuclear reactors, it is imperative to understand the effects of various dopants (Ti, Th, and Zr) on the solubility of the fission product Xe in UO2.
Liu Pan, Zhen Wang, Qingqing Wang, Zhixiao Liu, Min Pan, Zheng Huang, Lu Wu   +6 more
doaj   +1 more source

Statistically interacting vacancy particles [PDF]

, 2014
The equilibrium statistical mechanics of one-dimensional lattice gases with interactions of arbitrary range and shape between first-neighbor atoms is solved exactly on the basis of statistically interacting vacancy particles.
Bakhti, Benaoumeur, Karbach, Michael, Maass, Philipp, Mokim, Mohammad, Muller, Gerhard   +4 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Electronic structure of vacancy resonant states in graphene: a critical review of the single vacancy case

, 2013
The resonant behaviour of vacancy states in graphene is well-known but some ambiguities remain concerning in particular the nature of the so-called zero energy modes.
Ducastelle, François
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

TRENDS OF CHANGES IN THE LABOR MARKET FOR GRADUATES OF IT SPECIALTIES AND EMPLOYMENT OPPORTUNITIES IN STACK 1C

Наука Красноярья
Changes in the labor market are constantly occurring, and the IT specialist market is no exception. In this field, it is important to follow new trends in order to remain in demand as a specialist.
Aleksandra L. Posokhova, Natal'ya D. Ul'yanova, Elena M. Milyutina   +2 more
doaj   +1 more source

Cavity QED with Diamond Nanocrystals and Silica Microspheres

, 2006
Normal mode splitting is observed in a cavity QED system, in which nitrogen vacancy centers in diamond nanocrystals are coupled to whispering gallery modes in a silica microsphere.
Armani D. K., Beveratos A., Boca A., Braginsky V. B., Buck J. R., Cai M., Cavity Quantum Electrodynamics, Cirac J. I., Fan X., Jelezko F., Jelezko F., Jelezko F., Kennedy T. A., Kimble H., Kuhn S., Kurtsiefer C., Lacey S., Lacey S., Le Thomas N., Lefevre-Seguin V., Mabuchi H., Maunz P., Pellizzari T., Raimond J. M., Redman D., Reithmaier J. P., Spillane S. M., Treussart F., Wallraff A., Wang H., Yao W., Yoshie T.   +31 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source