Results 331 to 340 of about 1,370,088 (427)

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
wiley   +1 more source

Epidemiological trends and clinical characteristics of measles in Iraq (2023-2024): a retrospective cross-sectional study. [PDF]

BMC Infect Dis
Jalal MA, Halboot KM, Lami SA, Gumar EA, Al-Delphi MHK, Lami F, Taher TMJ.   +6 more
europepmc   +1 more source

RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer

Advanced Science, EarlyView.
RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong, Siming Chen, Huimin Xu, Sheng Tu, Hong Weng, Yejinpeng Wang, Mingxing Li, Jingtian Yu, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Gang Wang   +13 more
wiley   +1 more source

Impact of Dark Triad personality traits on COVID-19 vaccination uptake and prevention efforts: insights from the European Covid Survey (ECOS). [PDF]

BMC Public Health
Bock S, Neumann-Böhme S, Steinorth P.
europepmc   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

Influenza Vaccination Among People With Medicare by Race and Ethnicity, Education, and Rurality.

JAMA Netw Open
Gidengil C, Haviland A, Hambarsoomian K, Martino S, Dembosky JW, Elliott MN.   +5 more
europepmc   +1 more source

Hepatitis B virus infection after immunization: How serious it is? An updated review. [PDF]

Clin Exp Med
Marjani A, Alavian SM, Nassiri Toosi M, Alavian SH, Abazari MF, Khamseh A, Jazayeri SM.   +6 more
europepmc   +1 more source

THE SIGNIFICANCE OF OCULAR COMPLICATIONS FOLLOWING VACCINATION

, 1949
Eric Rosen
openalex   +1 more source

Fc Proteoforms of ACPA IgG Discriminate Autoimmune Responses in Plasma and Synovial Fluid of Rheumatoid Arthritis Patients and Associate with Disease Activity

Advanced Science, EarlyView.
Rheumatoid arthritis is a prototypic autoimmune disease characterized by highly prevalent autoantibodies – anti‐citrullinated protein antibodies (ACPA). A novel nanoHPLC‐MS approach based on the intact Fc/2 subunit identifies hitherto neglected Fc proteoform profiles of IgG (auto)antibodies across different biofluids. The findings demonstrate subclass‐
Constantin Blöchl, Eva Maria Stork, Hans Ulrich Scherer, Rene E. M. Toes, Manfred Wuhrer, Elena Domínguez‐Vega   +5 more
wiley   +1 more source

A cost-effectiveness analysis of adult human papillomavirus vaccination strategies in Italy. [PDF]

Hum Vaccin Immunother
Cherif A, Palmer C, Senese F, Bechini A, Salvati C, Bonanni P, Boccalini S.   +6 more
europepmc   +1 more source