Results 261 to 270 of about 222,471 (336)

A Closed‐Loop Hybrid Discovery System of Type I Photosensitizers for Hypoxic Tumor Therapy

Advanced Science, EarlyView.
The work developed a closed‐loop hybrid discovery system to rationally design and predict high‐performance Type I PSs for hypoxic tumor therapy. 664 Potential candidates are identified from a dataset through a support vector machine (SVM) classification model, and two candidates are experimentally verified as Type I PSs, which highlighted the potential
Xia Ling, Yixin Zhu, Min Li, Zongliang Xie, Lei Cao, Wentao Song, Dandan Wang, Duo Mao, Xiaonan Wang, Bin Liu   +9 more
wiley   +1 more source

Tracking the progress of maternal pertussis vaccination coverage among upper-middle- and high-income countries and territories - a systematic review and modeling study. [PDF]

EClinicalMedicine
Zhang X, Zhao T, Xie T, Zhang S, Xu Q, Cheng Y, Wei H, He A, Liu B, Lu QB, Jiang Y, Cui F.   +11 more
europepmc   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Analysis of factors driving HPV vaccination coverage and associated cost savings in the united States. [PDF]

BMC Public Health
Wang S, Muthukrishnan S, Quddus S, Manning SH, Brandt HM.   +4 more
europepmc   +1 more source

Evaluating the impact of the vaccination prescription program on herpes zoster vaccine coverage in Ningbo, China: An interrupted time series analysis [PDF]

Jianmei Wang, Jiaxin Wang, Ning Li, Dongkai Du, Dandan Zhang, Rui Ma   +5 more
openalex   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Trends in County-Level MMR Vaccination Coverage in Children in the United States.

JAMA
Dong E, Saiyed S, Nearchou A, Okura Y, Gardner LM.   +4 more
europepmc   +1 more source

Impact of the COVID-19 Pandemic on Routine Childhood Vaccination Coverage in Ecuador From 2019 to 2021: Comparative Analysis. [PDF]

JMIRx Med
Sanchez J, Rodriguez AA, Cuello KPM.
europepmc   +1 more source

Mpox vaccination coverage in the Democratic Republic of Congo: A systematic review and meta-analysis of uptake and acceptance (1970–2024) [PDF]

Fabrice Zobel Lekeumo Cheuyem, Adidja Amani, Adamu Abubakar Umar, Chabeja Achangwa, Brian Ngongheh Ajong, Solange Dabou, Jessy Goupeyou-Youmsi, Guy Roger Pilo Ndibo, Rick Tchamani, Ethel Ambo Eno, Jonathan Hangi Ndungo, Saralees Nadarajah   +11 more
openalex   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source