Results 91 to 100 of about 283,427 (308)

A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity [PDF]

, 2017
Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote ...
Brossard, Natalie, Carmona, Carlos, Dergan Dylon, Leonardo Sebastian, Freire, Teresa, Noya, Verónica, Rabinovich, Gabriel Adrián, Rodríguez, Ernesto   +6 more
core   +1 more source

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines [PDF]

Journal of Visualized Experiments, 2018
The interest in DNA-based vaccination has increased during the past two decades. DNA vaccination is based on the cloning of a sequence of a selected antigen or a combination of antigens into a plasmid, which enables a tailor-made and safe design. The administration of DNA vaccines into host cells leads to the expression of antigens that stimulate both ...
Myllymäki, H, Niskanen, M, Oksanen, K, Rämet, M   +3 more
openaire   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A Breath of Fresh Air: BCG Prevents Adult Pulmonary Tuberculosis

International Journal of Infectious Diseases, 2019
Objectives: The efficacy of childhood BCG vaccination in the prevention of adult pulmonary tuberculosis is not universally accepted. Methods: We reviewed the published literature and summarized studies of BCG vaccination reporting long-term protection ...
David de Gijsel, C. Fordham von Reyn
doaj   +1 more source

Estimating the size of dog populations in Tanzania to inform rabies control [PDF]

, 2018
Estimates of dog population sizes are a prerequisite for delivering effective canine rabies control. However, dog population sizes are generally unknown in most rabies-endemic areas.
Changalucha, Joel, Cleaveland, Sarah, Hampson, Katie, Johnson, Paul C.D., Lembo, Tiziana, Lushasi, Kennedy, Mbunda, Eberhard, Mtema, Zacharia, Sambo, Maganga, Sikana, Lwitiko   +9 more
core   +1 more source

The effects of vaccine characteristics on adult women's attitudes about vaccination: A conjoint analysis study [PDF]

Vaccine, 2011
The number of current and future vaccines for adults has been steadily increasing. Yet, vaccine coverage rates for adult vaccinations have historically been low, and less is known about how adults in the mid-adult age range make vaccine decisions for themselves.
Melissa S, Stockwell, Susan L, Rosenthal, Lynne A, Sturm, Rose M, Mays, Rita M, Bair, Gregory D, Zimet   +5 more
openaire   +2 more sources

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Adult Vaccination Knowledge, Attitudes, and Behavior in Rural Tamil Nadu: A Cross-Sectional Study

National Journal of Community Medicine
Background: Adult vaccination is a crucial yet underutilized component of public health, especially in rural areas where access to healthcare services is limited.
Kiruthika Narayanan, Shanthi Edward, Krishna Prasanth   +2 more
doaj   +1 more source

Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora [PDF]

, 2018
The protective capacities of a native double-domain activation-associated secreted protein (ndd-ASP)-based vaccine against the cattle intestinal nematode Cooperia oncophora has previously been demonstrated.
Borloo, Jimmy, Casaert, Stijn, Claerebout, Edwin, Geldhof, Peter, González Hernández, Ana, Leclercq, Georges, Peelaers, Iris   +6 more
core   +1 more source